cAMP modulates an S-type K+ channel coupled to GABAB receptors in mammalian respiratory neurons.
cAMP modulates an S-type K+ channel coupled to GABAB receptors in mammalian respiratory neurons.
复制标题
cAMP 调节哺乳动物呼吸神经元中与 GABAB 受体偶联的 S 型 K 通道。
DOI：
10.1097/00001756-199705060-00021
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发表时间：
1997
期刊：
影响因子：
1.7
通讯作者：
Dekin,MS
中科院分区：
文献类型：
--
作者：
Wagner,PG;Dekin,MS
PREMOTOR respiratory neurons from neonatal rats express a Ba 2+-insensitive outward rectifying K+ channel (K OR) which is activated by γ-aminobutyric acid acting at its β receptor. The biophysical properties of K OR are similar to those described for the S-channel (K S) which underlies simple forms of non-associative learning in the marine mollusc Aplysia. We show here that K OR, like the S-channel, is inhibited by cAMP. In addition, we demonstrate that this inhibition is due to a change in closed time kinetics. Our data suggests that the ionic and biochemical substrates underlying synaptic plasticity in Aplysia have been phylogenetically conserved in mammalian motor circuits such as that controlling rhythmic breathing movements.
