RECOVERY OF ACUTELY TRANSFORMING VIRUSES FORM MYELOID LEUKOSIS INDUCED BY THE HPRS-103 STRAIN OF AVIAN-LEUKOSIS VIRUS
RECOVERY OF ACUTELY TRANSFORMING VIRUSES FORM MYELOID LEUKOSIS INDUCED BY THE HPRS-103 STRAIN OF AVIAN-LEUKOSIS VIRUS
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DOI：
10.2307/1591671
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发表时间：
1993-04-01
期刊：
影响因子：
1.4
通讯作者：
HOWES, K
中科院分区：
文献类型：
--
作者：
PAYNE, LN;GILLESPIE, AM;HOWES, K
Viruses rapidly able to transform cultured chicken bone-marrow cells have been isolated from cases of myelocytic myeloid leukosis (MML) induced experimentally by the HPRS-103 strain of avian leukosis virus, and from field cases of MML. HPRS-103 virus itself did not acutely transform cultured bone-marrow cells. These findings suggest that during myeloid leukemogenesis by HPRS-103 virus, recombinant viruses are generated with transduced cellular oncogenes. The transformed cell appeared to be a macrophage precursor cell. Transformed cells in culture lost their proliferative capacity after a few weeks and then tended to resemble more differentiated macrophages. This change could be reversed temporarily by addition of a myelomonocytic growth factor, cMGF, to the culture medium.In oncogenicity tests, a selection of the virus strains induced MML, nephroblastomas, renal adenomas/adenocarcinomas, and other tumors in line 21 meat-type chickens but not in line 0 chickens. This difference may have been related to a propensity for the virus strains to induce persistent tolerant viremic infections in the line 21 chickens following infection at 1 day of age. The oncogenic pattern was not clearly related to the ability of the viruses to transform cultured bone-marrow cells.The generation of acutely transforming viruses during myeloid leukemogenesis may be relevant to the occurrence of MML in the field.
