Reprints Available Directly from the Publisher Photocopying Permitted by License Only Diabetes in Old Male Offspring of Rat Dams Fed a Reduced Protein Diet
Reprints Available Directly from the Publisher Photocopying Permitted by License Only Diabetes in Old Male Offspring of Rat Dams Fed a Reduced Protein Diet
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直接从出版商处获得重印 仅经许可才允许复印 喂食低蛋白饮食的老年雄性大鼠后代患有糖尿病
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通讯作者：
C. Hales
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作者：
Clive J Petrya;Matthew W Dorlinga;Dorota B Pawlakb;Susan E. Ozanne;C. Hales
胎儿生长受限与人类未来发展为2型糖尿病的风险增加有关。本研究的目的是评估老龄（17个月）雄性大鼠的糖耐量，这些大鼠在妊娠期和哺乳期由于母体蛋白质限制而在早期生长受限。给老鼠母亲喂食含有20%或8%蛋白质的饮食，所有的后代断奶后都吃标准的老鼠饮食。静脉葡萄糖耐量试验中，老年空腹大鼠低蛋白区血浆葡萄糖浓度显著升高，曲线下葡萄糖浓度升高67% (p =0.01)，胰岛素浓度升高81% (p =0.01)，提示（一定程度）胰岛素抵抗。这些结果表明，由于母体蛋白质限制导致的早期生长迟缓导致老年雄性大鼠后代糖尿病的发展。糖尿病主要与胰岛素抵抗有关。表型与人类代谢综合征有一些相似之处。[2] 31然而，尽管大鼠模型有更大的与年龄相关的糖耐量下降，但尚未观察到弗兰克糖尿病。[1,21]这可能是因为这些大鼠没有在老年时被研究过。因此，我们对17个月大的雄性大鼠进行了研究。提高静脉葡萄糖耐量和葡萄糖刺激胰岛素分泌。
Restricted fetal growth is associated with increased risk for the future development of Type 2 diabetes in humans. The study aim was to assess the glucose tolerance of old (seventeen months) male rats, which were growth restricted in early life due to maternal protein restriction during gestation and lactation. Rat mothers were fed diets containing either 20% or 8% protein and all offspring weaned onto a standard rat diet. In old-age fasting plasma glucose concentrations were significantly higher in the low protein off-Areas under the curves were increased by 67% for glucose (p =0.01) and 81% for insulin (p =0.01) in these rats in intravenous glucose tolerance tests, suggesting (a degree of) insulin resistance. These results show that early growth retardation due to maternal protein restriction leads to the development of diabetes in old male rat offspring. The diabetes is predominantly associated with insulin resistance. phenotype which shows some similarities to that of the metabolic syndrome in humans. [2'31 However despite the rat model having a greater age-related loss of glucose tolerance, frank diabetes has not been observed. I1,21 This may be because the rats have not been studied at an advanced age. We have therefore carried out studies of seventeen month old male rats to dete.rmine their intravenous glucose tolerance and glucose-stimulated insulin secretion.