Origin and evolution of the Drosophila Y chromosome
Origin and evolution of the Drosophila Y chromosome
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DOI：
10.1016/s0959-437x(02)00356-8
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发表时间：
2002-12-01
影响因子：
4
通讯作者：
Carvalho, AB
中科院分区：
文献类型：
--
作者：
Carvalho, AB
最近的三项发现对我们理解果蝇Y染色体产生了深远的影响。首先，果蝇基因组的测序和适当的计算方法的发展使已知的单拷贝Y连锁基因的数量从1个增加到16个，并揭示了一条染色体，其中充满了从常染色体获得的基因。第二，这一点，再加上B染色体能够显示出与X染色体非常规则的分离，加强了果蝇Y是一个特化的B染色体，而不是X染色体的退化同源物的假设。第三，也是最后一点，Y染色体似乎对男性健康有很大的影响。
Three recent findings are making a deep impact on our understanding of the Drosophila Y. First, the sequencing of the Drosophila genome and the development of proper computational methods increased the number of known single-copy Y-linked genes from 1 to 16, and revealed a chromosome packed with genes acquired from the autosomes. Second, this, coupled with the finding that B-chromosomes are able to show very regular segregation from the X chromosome, reinforce the hypothesis that the Drosophila Y is a specialized B-chromosome, instead of a degenerated homologue of the X. Third and finally, Y chromosomes seem to have a strong effect on male fitness.