INCREASED NEUROVIRULENCE ASSOCIATED WITH A SINGLE NUCLEOTIDE CHANGE IN A NONCODING REGION OF THE SABIN TYPE-3 POLIOVACCINE GENOME
INCREASED NEUROVIRULENCE ASSOCIATED WITH A SINGLE NUCLEOTIDE CHANGE IN A NONCODING REGION OF THE SABIN TYPE-3 POLIOVACCINE GENOME
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DOI：
10.1038/314548a0
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发表时间：
1985-01-01
期刊：
影响因子：
64.8
通讯作者：
MAIZEL, JV
中科院分区：
文献类型：
--
作者：
EVANS, DMA;DUNN, G;MAIZEL, JV
在使用Sabin的减毒脊髓灰质炎病毒疫苗的国家发生的少数脊髓灰质炎病例中，大多数与接种疫苗暂时有关，涉及2型和3型脊髓灰质炎病毒（参考文献1）。最近的研究提供了令人信服的证据，表明Sabin 2型和3型病毒本身在man2-6传代时可能恢复为神经毒性表型。我们在此报告，在从疫苗相关脊髓灰质炎病例分离的株中，脊髓灰质炎病毒3型疫苗基因组5 '非编码区的一个点突变始终恢复为野生型。具有这种变化的病毒在通过人体胃肠道时被迅速选择。这种变化与病毒的神经毒性明显增加有关。
Most of the small number of cases of poliomyelitis which occur in countries where Sabin's attenuated poliovirus vaccines are used are temporally associated with administration of vaccine and involve polioviruses of types 2 and 3 (ref. 1). Recent studies have provided convincing evidence that the Sabin type 2 and 3 viruses themselves may revert to a neurovirulent phenotype on passage in man2–6. We report here that a point mutation in the 5′ noncoding region of the genome of the poliovirus type 3 vaccine consistently reverts to wild type in strains isolated from cases of vaccine-associated poliomyelitis. Virus with this change is rapidly selected on passage through the human gastrointestinal tract. The change is associated with a demonstrable increase in the neurovirulence of the virus.