Autophagy in cardiac metabolic control: Novel mechanisms for cardiovascular disorders
Autophagy in cardiac metabolic control: Novel mechanisms for cardiovascular disorders
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DOI：
10.1002/cbin.10626
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发表时间：
2016-09
影响因子：
3.9
通讯作者：
Yufei Yang;Cong Zhao;Pingzhen Yang;Xianbao Wang;Lizi Wang;Aihua Chen
中科院分区：
文献类型：
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作者：
Yufei Yang;Cong Zhao;Pingzhen Yang;Xianbao Wang;Lizi Wang;Aihua Chen
自噬作为一种被广泛研究的质量控制系统，负责清除细胞中功能失调的细胞器和受损的小分子。自噬除了具有生物循环功能外，在肥胖和糖尿病等代谢综合征的发病机制中也起着重要作用。特别是，代谢紊乱有助于心血管疾病的发展。由于维持心脏细胞功能所需的能量是巨大的，合成代谢和分解代谢之间的平衡紊乱可能导致心血管疾病。因此，迫切需要扩大我们对自噬在心脏代谢调节中的作用的认识。在这篇综述中，自噬活性和心脏代谢之间的潜在关系进行了探讨，我们还讨论了失调的自噬如何导致严重的心脏疾病的代谢控制的角度。
As an extensively studied quality control system, autophagy is responsible for clearance of dysfunctional organelles and damaged marcomolecules in cells. In addition to its biological recycling function, autophagy plays a significant role in the pathogenesis of metabolic syndromes such as obesity and diabetes. In particular, metabolic disorders contribute to cardiovascular disease development. As energy required to maintain cardiac cells functional is immense, disturbances in the balance between anabolic and catabolic metabolism possibly contribute to cardiovascular disorders. Therefore, an urgent need to expand our knowledge on the role of autophagy on the metabolic regulation of hearts emerges. In this review, the potential relationship between autophagic activity and cardiac metabolism is explored and we also discuss how dysregulated autophagy leads to severe cardiac disorders from the perspective of metabolic control.