NEUROTRANSMITTER SYNTHESIS BY NEUROBLASTOMA CLONES
NEUROTRANSMITTER SYNTHESIS BY NEUROBLASTOMA CLONES
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DOI：
10.1073/pnas.69.1.258
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发表时间：
1972-01-01
影响因子：
11.1
通讯作者：
RICHELSON, E
中科院分区：
文献类型：
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作者：
AMANO, T;NIRENBERG, M;RICHELSON, E
检查神经母细胞瘤克隆的胆碱乙酰转移酶(EC 2.3.1.6)、酪氨酸羟化酶(EC 1.14.3.a)、乙酰胆碱酯酶(EC 3.1.1.7)以及神经突形成。一个克隆不形成轴突或树突。在神经递质合成方面发现了三种类型的克隆：胆碱能克隆、肾上腺素能克隆和不合成乙酰胆碱或儿茶酚的克隆。所有克隆均含有乙酰胆碱酯酶。这些结果表明，决定神经递质种类的基因可以在分裂细胞中表达，基因表达的亲本程序是遗传的，并且分裂细胞可以根据其与其他细胞沟通的能力进行编程。
Neuroblastoma clones were examined for choline acetyltransferase (EC 2.3.1.6), tyrosine hydroxylase (EC 1.14.3.a), acetylcholinesterase (EC 3.1.1.7), and also for neurite formation. One clone does not form axons or dendrites. Three types of clones were found with respect to neurotransmitter synthesis: cholinergic, adrenergic, and clones that do not synthesize acetylcholine or catechols. All clones contain acetylcholinesterase. These results show that genes determining neurotransmitter species can be expressed in dividing cells, that the parental programs of gene expression are inherited, and that dividing cells can be programmed with respect to their ability to communicate with other cells.