ERG Rearrangement for Predicting Subsequent Cancer Diagnosis in High-Grade Prostatic Intraepithelial Neoplasia and Lymph Node Metastasis
ERG Rearrangement for Predicting Subsequent Cancer Diagnosis in High-Grade Prostatic Intraepithelial Neoplasia and Lymph Node Metastasis
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ERG 重排预测高级别前列腺上皮内瘤变和淋巴结转移的后续癌症诊断
DOI：
10.1158/1078-0432.ccr-11-2449
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发表时间：
2012-06
影响因子：
11.5
通讯作者：
Pang, Jun
中科院分区：
文献类型：
--
作者：
Chen, Zhong;Li, Liao-Yuan;Zhou, Fang-Jian;Xie, Ke-Ji;Shao, Chun-Kui;Su, Zu-Lan;Sun, Qi-Peng;Chen, Ming-Kun;Pang, Jun
目的：我们的目的是分析活检组织中的ERG重排是否可用于评估高级别前列腺上皮内瘤变（HGPIN）的后续癌症诊断和早期前列腺癌的淋巴结转移风险。实验设计：前瞻性收集了523例患者（361例早期前列腺癌和162例HGPIN）的样本。根据先前确定的临界值，将162例HGPIN患者分为两组：一组ERG重排率≥1.6%（n = 59），另一组ERG重排率<1.6%（n = 103）。在361例接受根治性前列腺癌切除术的患者中，143例接受了盆腔淋巴结清扫术（淋巴结阳性，n = 56，淋巴结阴性，n = 87）。所有ERG重排FISH数据均用ERG免疫组化进行验证。结果如下：在重复活检随访期间，ERG重排率≥1.6%的56例（59例，94.9%）HGPIN和ERG重排率<1.6%的5例（103例，4.9%）HGPIN被诊断为前列腺癌（P < 0.001）。淋巴结阳性与淋巴结阴性的前列腺癌ERG重排率有显著性差异（P < 0.001）。ERG重排预测淋巴结转移的最佳临界值为2.6%，敏感性为80.4% [95%置信区间（CI），67.6-89.8]，特异性为85.1%（95% CI，75.8-91.8）。免疫组化检测ERG蛋白表达与FISH检测ERG重排高度一致。结论：首次活检时发现HGPIN病变中存在ERG重排，需要重复活检，测量ERG重排可用于评估早期前列腺癌淋巴结转移的风险。临床癌症研究; 18（15）; 4163-72。©2012 AACR。
Purpose: We aimed to analyze whether ERG rearrangement in biopsies could be used to assess subsequent cancer diagnosis in high-grade prostatic intraepithelial neoplasia (HGPIN) and the risk of lymph node metastasis in early prostate cancer. Experimental Design: Samples from 523 patients (361 with early prostate cancer and 162 with HGPIN) were collected prospectively. On the basis of the cutoff value established previously, the 162 patients with HGPIN were stratified to two groups: one with an ERG rearrangements rate ≥1.6% (n = 59) and the other with an ERG rearrangements rate <1.6% (n = 103). For the 361 prostate cancer cases undergoing radical prostatectomy, 143 had pelvic lymph node dissection (node-positive, n = 56 and node-negative, n = 87). All ERG rearrangement FISH data were validated with ERG immunohistochemistry. Results: A total of 56 (of 59, 94.9%) HGPIN cases with an ERG rearrangements rate ≥1.6% and 5 (of 103, 4.9%) HGPIN cases with an ERG rearrangements rate <1.6% were diagnosed with prostate cancer during repeat biopsy follow-ups (P < 0.001). There were significant differences in ERG rearrangement rates between lymph node–positive and -negative prostate cancer (P < 0.001). The optimal cutoff value to predict lymph node metastasis by ERG rearrangement was established, being 2.6% with a sensitivity at 80.4% [95% confidence interval (CI), 67.6–89.8] and a specificity at 85.1% (95% CI, 75.8–91.8). ERG protein expression by immunohistochemistry was highly concordant with ERG rearrangement by FISH. Conclusions: The presence of ERG rearrangement in HGPIN lesions detected on initial biopsy warrants repeat biopsies and measuring ERG rearrangement could be used for assessing the risk of lymph node metastasis in early prostate cancer. Clin Cancer Res; 18(15); 4163–72. ©2012 AACR.
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影响因子：
30.8
作者：
Carver, Brett S.;Tran, Jennifer;Gopalan, Anuradha;Chen, Zhenbang;Shaikh, Safa;Carracedo, Arkaitz;Alimonti, Andrea;Nardella, Caterina;Varmeh, Shohreh;Scardino, Peter T.;Cordon-Cardo, Carlos;Gerald, William;Pandolfi, Pier Paolo
通讯作者：
Pandolfi, Pier Paolo
DOI：
10.1097/s0022-5347(01)68600-2
发表时间：
2005-10
期刊：
The Journal of urology
影响因子：
--
作者：
P. Walsh
通讯作者：
P. Walsh
DOI：
10.1016/j.urolonc.2007.07.004
发表时间：
2007-09
影响因子：
2.7
作者：
A. Kibel
通讯作者：
A. Kibel
DOI：
10.1097/01.pas.0000213324.97294.54
发表时间：
2006-09
期刊：
The American Journal of Surgical Pathology
影响因子：
--
作者：
G. Netto;J. Epstein
通讯作者：
G. Netto;J. Epstein
DOI：
10.1001/jama.1995.03530180039027
发表时间：
1995-11
期刊：
JAMA
影响因子：
--
作者：
S. Jacobsen;S. Katusic;E. Bergstralh;J. E. Oesterling;Del Ohrt;G. Klee;C. Chute;M. Lieber
通讯作者：
S. Jacobsen;S. Katusic;E. Bergstralh;J. E. Oesterling;Del Ohrt;G. Klee;C. Chute;M. Lieber