Increased US prescription trends associated with the CDC Bacillus anthracis antimicrobial postexposure prophylaxis campaign
Increased US prescription trends associated with the CDC Bacillus anthracis antimicrobial postexposure prophylaxis campaign
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DOI：
10.1002/pds.828
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发表时间：
2003-04-01
影响因子：
2.6
通讯作者：
Murphy, D
中科院分区：
文献类型：
--
作者：
Shaffer, D;Armstrong, G;Murphy, D
目的 我们评估了与美国第一例因有意输送炭疽杆菌 (B. anthracis) 孢子而导致的吸入性炭疽病例相关的全国门诊抗菌药物处方趋势。方法 我们查询了 IMS HEALTH 的国家处方审计 PIus7(TM) 数据库 2001 年和 2000 年两个 6 个月期间（7 月至 12 月），以描述在 2001 年和 2000 年期间推荐的抗菌药物的门诊处方趋势。疾病控制和预防中心 (CDC) 的暴露后预防活动。 结果 总体而言，与 2001 年相比，2000 年 6 个月时间范围内的抗菌药物使用量更高。相比之下，2001 年 10 月（指示病例的下一个月）环丙沙星的使用量更高，比 2000 年 10 月的使用量增加了 40% 以上。同样，强力霉素的使用量在 2001 年 10 月期间增加了 30%。十月/十一月。这与美国 10 月份环丙沙星使用量相对增加约 160000 份处方、10 月份使用多西环素约 96000 份处方以及 11 月使用 120000 份处方相对增加。 结论 我们得出的结论是，在应对美国首次与生物恐怖分子相关的炭疽袭击时，环丙沙星和多西环素的处方使用范围比根据已确诊或疑似炭疽杆菌所保证的情况要广泛。单独接触炭疽病。 John Wiley Sons, Ltd. 于 2003 年出版。
Purpose We evaluated national outpatient antimicrobial prescription trends in relation to the first United States case of inhalational anthrax due to the intentional delivery of Bacillus anthracis (B. anthracis) spores.Methods We queried IMS HEALTH's National Prescription Audit PIus7(TM) database for two 6-month periods (July-December) in 2001 and 2000 to describe outpatient prescription trends of antimicrobials recommended during the Centers for Disease Control and Prevention's (CDC) postexposure prophylaxis campaign.Results Overall, antimicrobial utilization for the referent 6-month time frame was greater in 2000 compared to 2001. In contrast, ciprofloxacin utilization was greater in 2001 during October, the month following the index case, increasing by more than 40% over utilization in October 2000. Similarly, doxycycline utilization increased by 30% during October/November. This corresponded to relative increases in US utilization for ciprofloxacin of approximately 160000 prescriptions for the month of October and for doxycycline of approximately 96000 prescriptions during October and 120000 prescriptions for November.Conclusions We conclude more widespread prescribing of ciprofloxacin and doxycycline occurred in response to the first US bioterrorist-associated anthrax attacks than was warranted based upon confirmed or suspected B. anthracis exposure alone. Published in 2003 by John Wiley Sons, Ltd.