To what extent is strain variation evidence for an independent genome in the agent of the transmissible spongiform encephalopathies?
To what extent is strain variation evidence for an independent genome in the agent of the transmissible spongiform encephalopathies?
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在传染性海绵状脑病的病原体中，菌株变异在多大程度上证明了独立基因组的存在？
DOI：
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
H. Baker
中科院分区：
文献类型：
--
作者：
R. Ridley;H. Baker
与海绵状脑病（朊病毒病）相关的多种“传播因子”的明显存在已被用来支持这样的论点：这些疾病是由具有自己的基因组的独立的复制因子引起的。然而，潜伏期的长度（从注射受感染物质到出现临床症状的时间）和病变特征（神经病理学的区域分布）是用于定义毒剂菌株的关键特征，已被证明受到宿主和供体的朊病毒蛋白的影响，因此在考虑了所有其他因素引起的变异后，只有这些测量值中保留的差异可以用作不同毒剂菌株存在的证据。供体是制备感染性物质用于注射到宿主体内的动物。发病机制的几乎所有方面，包括孵化时间的大部分差异，都可以用供体和宿主朊病毒蛋白之间的相互作用来解释。我们认为，单独的病原体菌株的数量可能比通常所表示的更为有限。重要的是要区分宿主朊病毒蛋白“允许”选择突变菌株的假设和它“诱导”病原体变化的假设。前者与具有独立基因组的病原体的概念一致，而后者与“病原体菌株”是朊病毒蛋白参与传染性海绵状脑病发病机制的另一种表达的概念一致。
The apparent existence of multiple strains of the 'transmissible agent' associated with spongiform encephalopathy (prion disease) has been used to support the argument that these diseases are caused by an independent, replicating agent with its own genome. However, the length of the incubation period (time from injection of infected material to onset of clinical signs) and the lesion profile (regional distribution of neuropathology), which are the key features used to define the strain of agent, have been shown to be influenced by the prion protein of the host and the donor, such that it is only the variance in these measures which remains after variation due to all other factors has been taken into account, which can be used as evidence for the existence of different strains of agent. The donor is the animal from which infectious material is prepared for injection into the host. Almost all aspects of pathogenesis, including most of the variance in incubation time, can be explained in terms of interactions between donor and host prion protein. We argue that the number of separate strains of agent may be more limited than is usually represented. It is important to distinguish between the hypothesis that the prion protein of the host 'permits' the selection of mutated strains and the hypothesis that it 'induces' changes in the agent. The former is consistent with the concept of an agent with an independent genome while the latter is consistent with the concept that 'strain of agent' is another expression of the involvement of prion protein in the pathogenesis of transmissible spongiform encephalopathy.
影响因子：
10.5
作者：
D. Westaway;V. Zuliani;C. Cooper;M. Da Costa;S. Neuman;A L Jenny;L. Detwiler;S. B. Prusiner
通讯作者：
D. Westaway;V. Zuliani;C. Cooper;M. Da Costa;S. Neuman;A L Jenny;L. Detwiler;S. B. Prusiner