Sleep Duration and Body Mass Index in Twins: A Gene-Environment Interaction

Sleep Duration and Body Mass Index in Twins: A Gene-Environment Interaction
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DOI：
10.5665/sleep.1810
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发表时间：
2012-05-01
期刊：
SLEEP
影响因子：
5.6
通讯作者：
Goldberg, Jack
Goldberg, Jack
中科院分区：
医学2区
文献类型：
--
作者：
Watson, Nathaniel F.;Harden, Kathryn Paige;Goldberg, Jack

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研究目的：检验睡眠时间是否会改变遗传和环境对体重指数(BMI)的影响。设计：基因-环境交互作用双胞胎研究。地点：华盛顿大学双胞胎登记处。患者或参与者：美国双胞胎的人群样本(1088对，604对同卵，484对同卵，66%女性，平均年龄=36.6岁，标准差=15.9岁)。干预：N/A。测量和结果：参与者自我报告有关身高、体重和睡眠的信息。平均体重指数为25.3 kg/m(2)(SD=5.4)，平均习惯性睡眠时间为7.2小时/夜(SD=1.2)。使用生物统计遗传交互模型对数据进行分析。总体而言，睡眠时间的遗传度为34%。睡眠时间越长，体重指数越低(P&lt；0.05)。睡眠时间为7小时(h(2)=70%)时BMI的遗传度是睡眠时间为9小时(h(2)=32%)时BMI遗传度的两倍多，这种交互作用具有统计学意义(P&lt；0.05)。结论：睡眠时间越短，BMI越高，对BMI的遗传影响越大，提示睡眠时间越短，高体重的遗传风险越高。同时，较长的睡眠时间可能会抑制基因对体重的影响。未来旨在确定BMI的特定基因类型的研究可能会受益于考虑睡眠时间的调节作用。
Study Objectives: To examine whether sleep duration modifies genetic and environmental influences on body mass index (BMI).Design: Genotype-environment interaction twin study.Setting: University of Washington Twin Registry.Patients or Participants: A population-based sample of US twins (1,088 pairs, 604 monozygotic, 484 dizygotic; 66% female; mean age = 36.6 yr, standard deviation (SD) = 15.9 yr).Interventions: N/A.Measurements and Results: Participants self-reported information on height, weight, and sleep. Mean BMI was calculated as 25.3 kg/m(2) (SD = 5.4) and mean habitual sleep duration was 7.2 hr/night (SD = 1.2). Data were analyzed using biometric genetic interaction models. Overall the heritability of sleep duration was 34%. Longer sleep duration was associated with decreased BMI (P < 0.05). The heritability of BMI when sleep duration was < 7 hr (h(2) = 70%) was more than twice as large as the heritability of BMI when sleep duration was >= 9 hr (h(2) = 32%); this interaction was significant (P < 0.05).Conclusions: Shorter sleep duration is associated with increased BMI and increased genetic influences on BMI, suggesting that shorter sleep duration increases expression of genetic risks for high body weight. At the same time, longer sleep duration may suppress genetic influences on body weight. Future research aiming to identify specific genotypes for BMI may benefit by considering the moderating role of sleep duration.