Peripheral blood chimerism following human liver transplantation
Peripheral blood chimerism following human liver transplantation
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DOI：
10.1002/hep.510250528
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发表时间：
1997-05-01
期刊：
影响因子：
13.5
通讯作者：
Powell, EE
中科院分区：
文献类型：
--
作者：
Jonsson, JR;Hogan, PG;Powell, EE
本研究的目的是前瞻性地研究肝移植后人类受体中供体白细胞嵌合体的峰值水平和动力学。仅在移植后的前48小时内观察到嵌合体的峰值水平，其范围为总外周血单核细胞的0.15%至20%。嵌合体的早期峰值水平随时间下降，使得供体白细胞仅在3至4周后间歇性地可检测到。在8例未发生移植物排斥反应的患者中，供体白细胞嵌合体的峰值水平范围为1.3%至20%（平均值± SEM; 5.5% ± 2.1%）。在3例术后4周内因急性排斥反应而接受治疗的患者中，供体白细胞嵌合体的峰值水平范围为0.15%至0.2%。（0.18 +/- 0.02，P = .012），结果表明肝移植后早期外周血中可检测到的供体白细胞总数有显著变化，较低水平的嵌合体可能与较低的初始移植物接受率和较高的急性排斥发生率有关。
The aim of this study was to prospectively investigate the peak levels and kinetics of donor leucocyte chimerism in human recipients following liver transplantation, The peak levels of chimerism mere observed within the first 48 hours following transplantation and ranged from 0.15% to 20% of total peripheral blood mononuclear cells, In all but one patient, who developed graft versus host disease, there was an early peak level of chimerism that declined over time such that donor leukocytes mere only intermittently detectable after 3 to 4 weeks. In 8 patients who had no episodes of graft rejection, the peak level of donor leukocyte chimerism ranged from 1.3% to 20% (mean +/- SEM; 5.5% +/- 2.1%). In 3 patients who were treated for episodes of acute graft rejection during the first four postoperative weeks, the peak level of donor leukocyte chimerism ranged from 0.15% to 0.2% (0.18 +/- 0.02, P = .012), The results demonstrate a marked variation in the total number of donor leukocytes detectable in the peripheral blood early after liver transplantation and also, that lower levels of chimerism may be associated with lower rates of initial graft acceptance and a higher incidence of acute rejection.