Dual Orthogonal Switching of the “Schizophrenic” Self-Assembly of Diblock Copolymers
Dual Orthogonal Switching of the “Schizophrenic” Self-Assembly of Diblock Copolymers
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DOI：
10.1021/acs.macromol.8b00096
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发表时间：
2018-03
期刊：
影响因子：
5.5
通讯作者：
N. Vishnevetskaya;Viet Hildebrand;M. Dyakonova;Bart‐Jan Niebuur;K. Kyriakos;K. Raftopoulos;Z. Di;P. Müller‐Buschbaum;A. Laschewsky;C. Papadakis
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文献类型：
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作者：
N. Vishnevetskaya;Viet Hildebrand;M. Dyakonova;Bart‐Jan Niebuur;K. Kyriakos;K. Raftopoulos;Z. Di;P. Müller‐Buschbaum;A. Laschewsky;C. Papadakis
基于二嵌段共聚物，通过将非离子和温敏性嵌段与两性离子的温敏性和盐敏性嵌段相结合，设计了一对“精神分裂”胶束体系。非离子嵌段是聚（N-异丙基丙烯酰胺）（PNIPAM）或聚（N-异丙基甲基丙烯酰胺）（PNIPMAM），并在水溶液中表现出较低的临界溶解温度（LCST）行为。两性离子嵌段是聚磺基甜菜碱，即，聚（4-（（3-甲基丙烯酰胺丙基）二甲基铵基）丁烷-1-磺酸盐）（PSBP），并具有上临界溶解温度（UCST）行为，其清亮点随盐浓度的增加而降低。通过连续可逆加成-断裂链转移（RAFT）聚合制备了PSBP-b-PNIPAM和PSBP-b-PNIPMAM两嵌段共聚物。选择PSBP嵌段使得均聚物在纯水中的澄清点显著高于PNIPAM或PNIPMAM的浊点。采用比浊法、核磁共振氢谱和小角中性差示扫描量热法测定。
Based on diblock copolymers, a pair of “schizophrenic” micellar systems is designed by combining a nonionic and thermoresponsive block with a zwitterionic block, which is thermoresponsive and salt-sensitive. The nonionic block is poly(N-isopropylacrylamide) (PNIPAM) or poly(N-isopropylmethacrylamide) (PNIPMAM) and exhibits a lower critical solution temperature (LCST) behavior in aqueous solution. The zwitterionic block is a polysulfobetaine, i.e., poly(4-((3-methacrylamidopropyl)dimethylammonio)butane-1-sulfonate) (PSBP), and has an upper critical solution temperature (UCST) behavior with the clearing point decreasing with increasing salt concentration. The PSBP-b-PNIPAM and PSBP-b-PNIPMAM diblock copolymers are prepared by successive reversible addition–fragmentation chain transfer (RAFT) polymerizations. The PSBP block is chosen such that the clearing point of the homopolymer is significantly higher in pure water than the cloud point of PNIPAM or PNIPMAM. Using turbidimetry, 1H NMR, and small-angle neut...