Phosphocreatine kinetics in the calf muscle of patients with bilateral symptomatic peripheral arterial disease during exhaustive incremental exercise
Phosphocreatine kinetics in the calf muscle of patients with bilateral symptomatic peripheral arterial disease during exhaustive incremental exercise
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DOI：
10.1007/s11307-007-0118-z
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发表时间：
2008-01-01
影响因子：
3.1
通讯作者：
Greiner, Andreas
中科院分区：
文献类型：
--
作者：
Esterhammer, Regina;Schocke, Michael;Greiner, Andreas
目的：研究双侧症状性外周动脉疾病（PAD）患者在递增、力竭性小腿运动过程中，磁共振血管造影（MRA）测定的动脉粥样硬化病变负荷与磷酸肌酸（PCr）动力学之间的关系。使用1.5特斯拉磁共振扫描仪，26例双侧症状性PAD患者和24例健康男性对照者在2、3、4和5 W递增运动期间接受了系列磷-31 MR波谱（31 P MRS）。对于每个增量和回收率，根据MR光谱计算PCr时间常数、PCr变化幅度和pH值。在MRA上测定患者的径流阻力（ROR）。结果：患者表现出显着（C
Purpose: To investigate the relationship between the atherosclerotic lesion load determined on magnetic resonance angiography (MRA) and phosphocreatine (PCr) kinetics during incremental, exhaustive calf exercise in patients with bilateral, symptomatic peripheral arterial disease (PAD).Procedures: Using a 1.5 Tesla MR scanner, 26 patients with bilateral symptomatic PAD and 24 healthy male controls underwent serial phosphorus-31 MR spectroscopy (31P MRS) during incremental exercise at 2, 3, 4, and 5 Watts. For each increment and recovery, PCr time constants, amplitudes of PCr changes and pH values were calculated from the MR spectra. In patients, the run-off resistance (ROR) was determined on MRA.Results: The patients exhibited significantly (C