Manganese-Catalyzed β-Alkylation of Secondary Alcohols with Primary Alcohols under Phosphine-Free Conditions
Manganese-Catalyzed β-Alkylation of Secondary Alcohols with Primary Alcohols under Phosphine-Free Conditions
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无磷条件下锰催化仲醇与伯醇的 β-烷基化反应
DOI：
10.1021/acscatal.8b01960
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发表时间：
2018-08-01
期刊：
影响因子：
12.9
通讯作者：
Yu, Zhengkun
中科院分区：
文献类型：
--
作者：
Liu, Tingting;Wang, Liandi;Yu, Zhengkun
在无膦条件下，负载吡啶基负载的吡唑基-咪唑基配体的锰（I）配合物有效地催化仲醇与伯醇的直接β-烷基化。以中等至良好的产率获得β-烷基化仲醇，其中通过借氢途径形成水作为副产物。还有效地实现了胆固醇的β-烷基化。本协议提供了一个简洁的原子经济的方法CC键形成从伯和仲醇。
Manganese(I) complexes bearing a pyridyl-supported pyrazolyl-imidazolyl ligand efficiently catalyzed the direct beta-alkylation of secondary alcohols with primary alcohols under phosphine-free conditions. The beta-alkylated secondary alcohols were obtained in moderate to good yields with water formed as the byproduct through a borrowing hydrogen pathway. beta-Alkylation of cholesterols was also effectively achieved. The present protocol provides a concise atom-economical method for CC bond formation from primary and secondary alcohols.