What Is the Significance of Soluble and Endogenous Secretory Receptor for Advanced Glycation End Products in Liver Steatosis in Obese Prepubertal Children?
What Is the Significance of Soluble and Endogenous Secretory Receptor for Advanced Glycation End Products in Liver Steatosis in Obese Prepubertal Children?
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DOI：
10.1089/ars.2010.3719
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发表时间：
2011-03-01
影响因子：
6.6
通讯作者：
Mohn, Angelika
中科院分区：
文献类型：
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作者：
D'Adamo, Ebe;Giannini, Cosimo;Mohn, Angelika
晚期糖基化终末产物（ESRD）和可溶性糖基化终末产物（SRD）的内源性分泌型受体已在人血浆中显示，并且已成为包括胰岛素抵抗和肝损伤在内的几种病理状况的可靠生物标志物。我们检测了伴有和不伴有肝脂肪变性的青春期前肥胖儿童的雌二醇和睾酮水平。在患有脂肪肝的肥胖青春期前儿童中，雌二醇和雌二醇水平显著降低，并且与脂肪肝独立相关。这些发现表明，AGE-CRP通路在这个年龄组已经存在的肝损伤的发展中起着独立的作用。抗氧化剂。氧化还原信号。14，1167-1172.
The endogenous secretory receptor for advanced glycation end products (esRAGE) and soluble RAGE (sRAGE) have been shown in human plasma and have emerged as reliable biomarkers of several pathological conditions, including insulin resistance and liver injury. We examined esRAGE and sRAGE levels in obese prepubertal children with and without liver steatosis. esRAGE and sRAGE levels were significantly lower in obese prepubertal children affected by liver steatosis and were independently related to liver steatosis. These findings suggest that AGE-RAGE pathway plays an independent role in the development of liver injury already present in this age group. Antioxid. Redox Signal. 14, 1167-1172.