ZMM proteins during meiosis:: Crossover artists at work
ZMM proteins during meiosis:: Crossover artists at work
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DOI：
10.1007/s10577-007-1150-1
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发表时间：
2007-01-01
影响因子：
2.6
通讯作者：
Boerner, G. Valentin
中科院分区：
文献类型：
--
作者：
Lynn, Audrey;Soucek, Rachel;Boerner, G. Valentin
减数分裂过程中同源染色体（同源物）的忠实分离取决于交叉，交叉对应于亲本 DNA 链之间的交叉。交叉形成同源重组发生在联会复合体（SC）的背景下，联会复合体是一种并列同源物的蛋白质结构。分子重组事件和 SC 组装之间的协调作为提供同源物之间全局连接的结构代表了减数分裂的显着特征之一。 ZMM 蛋白（也称为突触起始复合物 = SIC）在两个过程中发挥着至关重要的作用，提供重组和 SC 组装之间的联系。 ZMM 组包括至少七种功能协作但结构多样的蛋白质：横丝蛋白 Zip1 通过聚合作为 SC 的组成部分建立稳定的同源并置。 Zip2、Zip3 和 Zip4 可能介导蛋白质-蛋白质相互作用，而 Mer3、Msh4 和 Msh5 直接促进 DNA 重组步骤。本综述重点关注对酵母减数分裂中 ZMM 功能的最新见解，并与其他模型生物中的 ZMM 相关蛋白进行比较。
Faithful segregation of homologous chromosomes (homologs) during meiosis depends on chiasmata which correspond to crossovers between parental DNA strands. Crossover forming homologous recombination takes place in the context of the synaptonemal complex (SC), a proteinaceous structure that juxtaposes homologs. The coordination between molecular recombination events and assembly of the SC as a structure that provides global connectivity between homologs represents one of the remarkable features of meiosis. ZMM proteins (also known as the synapsis initiation complex = SIC) play crucial roles in both processes providing a link between recombination and SC assembly. The ZMM group includes at least seven functionally collaborating, yet structurally diverse proteins: The transverse filament protein Zip1 establishes stable homolog juxtaposition by polymerizing as an integral component of the SC. Zip2, Zip3, and Zip4 likely mediate protein-protein interactions, while Mer3, Msh4, and Msh5 directly promote steps in DNA recombination. This review focuses on recent insights into ZMM functions in yeast meiosis and draws comparisons to ZMM-related proteins in other model organisms.