Rat brain digital stereotaxic white matter atlas with fine tract delineation in Paxinos space and its automated applications in DTI data analysis
Rat brain digital stereotaxic white matter atlas with fine tract delineation in Paxinos space and its automated applications in DTI data analysis
复制标题
Paxinos 空间中具有细路描绘的大鼠脑数字立体定位白质图谱及其在 DTI 数据分析中的自动化应用
DOI：
10.1016/j.mri.2017.07.011
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发表时间：
2017-11-01
影响因子：
2.5
通讯作者：
Shan, Baoci
中科院分区：
文献类型：
--
作者：
Liang, Shengxiang;Wu, Shang;Shan, Baoci
目的：为了通过基于体素和基于感兴趣区域的方法自动分析大鼠大脑的扩散张量图像，我们在帕西诺斯（Paxinos）和沃森（Watson）空间构建了一个具有精细纤维束描绘的新的大鼠大脑白质图谱。
材料和方法：与以往研究不同，我们根据帕西诺斯和沃森的最新版本构建了一个数字图谱图像。该图谱包含111条精心描绘的白质纤维。通过定位所有这些纤维束的交叉点并记录每条白质纤维束路径上的神经核，构建了一个基于解剖学的大鼠大脑白质网络。此外，从扩散张量成像（DTI）图像创建了一个兼容的大鼠大脑模板，并将其标准化到图谱空间。为了评估该图谱在DTI数据分析中的自动化应用，本研究纳入了一组大脑中动脉右侧闭塞（MCAO）的大鼠和未闭塞的大鼠。
结果：基于体素的分析结果表明，MCAO大鼠中信号显著下降的大脑区域与闭塞位置一致。
结论：我们构建了一个具有精细纤维束描绘的大鼠大脑立体定位白质图谱以及一个用于大鼠大脑DTI图像数据分析的兼容模板。（C）2017爱思唯尔公司。保留所有权利。
Purpose: To automatically analyze diffusion tensor images of the rat brain via both voxel-based and ROl-based approaches, we constructed a new white matter atlas of the rat brain with fine tracts delineation in the Paxinos and Watson space.Materials and methods: Unlike in previous studies, we constructed a digital atlas image from the latest edition of the Paxinos and Watson. This atlas contains 111 carefully delineated white matter fibers. A white matter network of rat brain based on anatomy was constructed by locating the intersection of all these tracts and recording the nuclei on the pathway of each white matter tract. Moreover, a compatible rat brain template from DTI images was created and standardized into the atlas space. To evaluate the automated application of the atlas in DTI data analysis, a group of rats with right-side middle cerebral artery occlusion (MCAO) and those without were enrolled in this study.Results: The voxel-based analysis result shows that the brain region showing significant declines in signal in the MCAO rats was consistent with the occlusion position.Conclusion: We constructed a stereotaxic white matter atlas of the rat brain with fine tract delineation and a compatible template for the data analysis of DTI images of the rat brain. (C) 2017 Elsevier Inc. All rights reserved.