A thermally stable {FeNO}8 complex: properties and biological reactivity of reduced MNO systems
A thermally stable {FeNO}8 complex: properties and biological reactivity of reduced MNO systems
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DOI：
10.1039/c1sc00582k
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发表时间：
2012-01-01
期刊：
影响因子：
8.4
通讯作者：
Harrop, Todd C.
中科院分区：
文献类型：
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作者：
Patra, Ashis K.;Dube, Koustubh S.;Harrop, Todd C.
还原的氮氧化物配体，如NO-/HNO或硝基参与不同于一氧化氮（NO）的化学反应。硝基被提出在主中心形成，生成enemmark - feltham指定的{FeNO}(8)体系。用十甲基钴二烯[Co(Cp*)(2)]在甲苯中还原相应的{FeNO}(7)配合物[Fe(LN4)(NO)](1)，合成了热稳定的{FeNO}(8)物质[Co(Cp*)(2)][Fe (LN4)(NO)](3)，并置于类血红素配体平台上。该络合物很容易与metMb发生反应，通过配合物hno /NO-的还原性亚硝基化反应生成MbNO，而GSH可以抑制这一反应。这些结果表明，3可能是一种潜在的HNO治疗药物。对1和{CoNO}(8)配合物[Co(LN4)(NO)](2)（3的等电子类似物）进行了光谱、理论和结构比较。
Reduced nitrogen oxide ligands such as NO-/HNO or nitroxyl participate in chemistry distinct from nitric oxide (NO). Nitroxyl has been proposed to form at heme centers to generate the Enemark-Feltham designated {FeNO}(8) system. The synthesis of a thermally stable {FeNO}(8) species namely, [Co(Cp*)(2)][Fe (LN4)(NO)] (3), housed in a heme-like ligand platform has been achieved by reduction of the corresponding {FeNO}(7) complex, [Fe(LN4)(NO)] (1), with decamethylcobaltocene [Co(Cp*)(2)] in toluene. This complex readily reacts with metMb, resulting in formation of MbNO via reductive nitrosylation by the coordinatedHNO/NO-, which can be inhibited with GSH. These results suggest that 3 could serve as a potential HNO therapeutic. Spectroscopic, theoretical, and structural comparisons are made to 1 and the {CoNO}(8) complex, [Co(LN4)(NO)] (2), an isoelectronic analogue of 3.