but not older, brains are poised at a critical point of functional activity

but not older, brains are poised at a critical point of functional activity
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但年龄不大，大脑正处于功能活动的关键点

DOI：
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
K. Dill
K. Dill
中科院分区：
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文献类型：
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作者：
Corey Weistuch;L. Mujica;Anar Amgalan;K. Dill

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被引文献

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衰老与大脑区域之间交流的重大变化有关，但对这些变化的原理知之甚少。在这里，我们研究了年龄相关的葡萄糖代谢低下的作用，适应功能性MRI数据的伊辛模型。我们发现，年轻而非老年人的大脑处于临界点，促进了特定模式的整合和分离活动之间的切换，并与能量可用性的下降保持一致。
Aging is associated with significant changes in communication between brain regions, yet the principles governing these changes are poorly understood. Here, we examined the role of age-related glucose hypometabolism by adapting functional MRI data to the Ising model. We found that younger, but not older, brains are poised at a critical point, facilitating switching between specific patterns of integrated and segregated activity, and consistent with decreased energy availability.