Prolyl hydroxylase activity during sea urchin development.
Prolyl hydroxylase activity during sea urchin development.
复制标题
海胆发育过程中脯氨酰羟化酶活性。
DOI：
10.1016/0014-4827(80)90028-2
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发表时间：
1980
影响因子：
3.7
通讯作者：
A. Sessions
中科院分区：
文献类型：
--
作者：
S. Benson;A. Sessions
脯氨酰羟化酶活性出现在海胆 Strongylocentrotus purpuratus 的囊胚发育阶段，并在棱柱幼虫阶段增加超过 7 倍。该酶需要抗坏血酸、亚铁离子和 α-酮戊二酸才能发挥最大活性，并被 α,α'-联吡啶抑制。讨论了脯氨酰羟化酶活性在胚胎胶原代谢和形态发生中的重要性。
Prolyl hydroxylase activity appears at the blastula stage of development in the sea urchinStrongylocentrotus purpuratusand increases over 7-fold by the prism larva stage. The enzyme requires ascorbate, ferrous ions, and α-ketoglutarate for maximum activity and is inhibited by α,α′-dipyridyl. The significance of prolyl hydroxylase activity in embryonic collagen metabolism and morphogenesis is discussed.