Association Between Diet Inflammatory Index and Osteoporotic Hip Fracture in Elderly Chinese Population
Association Between Diet Inflammatory Index and Osteoporotic Hip Fracture in Elderly Chinese Population
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中国老年人饮食炎症指数与骨质疏松性髋部骨折的关系
DOI：
10.1016/j.jamda.2017.02.011
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发表时间：
2017
影响因子：
7.6
通讯作者：
Yu-ming Chen
中科院分区：
文献类型：
--
作者：
Zhe-qing Zhang;Wen-ting Cao;Nitin Shivappa;James R. Hebert;Bao-lin Li;Juan He;Xin-yi Tang;Ya-yong Liang;Yu-ming Chen
背景：慢性炎症为退行性骨折的各种机制提供了基础。饮食炎症指数（DII）可以揭示饮食的炎症潜力对骨质疏松性髋部骨折的影响。目的：本研究验证了中国老年人群中DII评分越高，髋部骨折风险越大的假设。方法：在中国广东（2009-2015年）对1050对（女性/男性：781/269）中国老年人（年龄范围= 52-83岁）进行了1：1年龄（±3岁）、性别和地区匹配的病例对照研究。病例为新诊断（2周内）髋部骨折患者，对照组来自社区（n = 835）或医院（n = 215）。DII评分是使用经验证的79项食物频率问卷从自我报告中计算出来的。通过条件Logistic回归估计DII评分的髋部骨折风险的比值比（OR）及其95%置信区间（CI）。结果：DII评分四分位数间髋部骨折的多变量校正OR（95%CI）分别为1（参考）、1.42（1.01，1.99）、1.63（1.16，2.28）和2.44（1.73，3.45）（P趋势<0.001）。比较极端四分位数，女性和男性受试者髋部骨折的调整OR（95% CI）分别为2.08（1.38，3.12）和4.30（1.89，9.80）（P相互作用= 0.26）。当按对照来源分层时，在社区对照组中观察到DII评分与髋部骨折风险之间存在剂量-反应正相关关系，但在医院对照组中未观察到（P相互作用= 0.16）。结论：促炎饮食似乎与髋部骨折风险呈正相关。
BACKGROUND:Chronic inflammation provides the substrate for various mechanisms involved in osteoporotic fracture. The Dietary Inflammatory Index (DII) could shed light on the effect of the inflammatory potential of the diet on osteoporotic hip fracture..OBJECTIVE:This study tested the hypothesis that higher DII scores are associated with greater hip fracture risk in an elderly Chinese population..METHODS:A 1:1 age- (±3 years), sex- and region-matched case-control study of 1050 pairs (female/male: 781/269) of elderly (age range = 52-83 years) Chinese was conducted in Guangdong, China (2009-2015). Cases were newly diagnosed (within 2 weeks) hip fracture patients and controls were recruited from either communities (n = 835 controls) or the hospital (n = 215). DII scores were calculated from self-reports using a validated 79-item food frequency questionnaire. Odds ratios (ORs) and their 95% confidence intervals (CIs) of the risk of hip fracture for DII scores were estimated from conditional logistic regression..RESULTS:The multivariable-adjusted ORs (95% CIs) for hip fracture across quartiles of DII scores were 1 (reference), 1.42 (1.01, 1.99), 1.63 (1.16, 2.28), and 2.44 (1.73, 3.45) (P trend <.001). Comparing extreme quartiles, the adjusted ORs (95% CIs) for hip fractures were 2.08 (1.38, 3.12) for female and 4.30 (1.89, 9.80) for male participants, respectively (P interaction = .26). When stratified by the source of controls, a dose-response positive relationship was observed between DII scores and hip fracture risk among community-based controls but not those from the hospital (P interaction = .16)..CONCLUSIONS:A proinflammatory diet appears to be positively associated with hip fracture risk.