Development of oral and pharyngeal teeth in the Medaka (Oryzias latipes):: Comparison of morphology and expression of eve1 gene
Development of oral and pharyngeal teeth in the Medaka (Oryzias latipes):: Comparison of morphology and expression of eve1 gene
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DOI：
10.1002/jez.b.21183
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发表时间：
2007-12-15
影响因子：
2.2
通讯作者：
Laurenti, Patrick
中科院分区：
文献类型：
--
作者：
Debiais-Thibaud, Melanie;Borday-Birraux, Veronique;Laurenti, Patrick
颌口牙齿是发育进化研究中最有前途的模型之一，它们是化石记录中最丰富的器官，也是器官发生的绝佳例子。牙齿具有复杂的形态，并且仅限于哺乳动物的口腔，而放线鱼的牙齿具有简单的形态，并且存在于多个位置，特别是在咽骨上。形态学和发育上的相似性支持了口腔和咽齿是连续同源的假设。来自小鼠和一些硬骨鱼的基因表达数据表明，参与咽牙形成的基因家族也参与口腔牙齿的形成，但 eux 基因家族除外。在这里，我们对青鳉（Oryzias latipes）的早期牙发育进行了完整的描述，青鳉具有口腔和咽部牙列。我们发现口腔和咽齿在发育上具有深刻的相似性。在青鳉鱼中，与斑马鱼一样，eve1 是在牙发育过程中唯一表达的 evx 基因。在每颗正在形成的牙齿中，无论其位置如何，eve1转录在基板中被激活，然后仅限于内部牙齿上皮，并在早期分化过程中在牙齿间充质中被激活，最后在分化晚期停止。因此，eve1 表达并不像之前所建议的那样特定于咽齿发育。由于青鳉可以通过分子、发育和功能研究直接比较口腔和咽部牙齿，因此青鳉是一个很好的模型，可以进一步深入了解颚类动物牙形成的进化。 J.Exp。动物园。 (Mol. Dev. Evol.) 308B:693-708, 2007。(c) 2007 Wiley-Liss, Inc.
Gnathostome teeth are one of the most promising models for developmental evolutionary studies, they are the most abundant organ in the fossil record and an excellent example of organogenesis. Teeth have a complex morphology and are restricted to the mouth in mammals, whereas actinopterygian teeth have a simple morphology and are found in several locations, notably on pharyngeal bones. Morphological and developmental similarities support the hypothesis that oral and pharyngeal teeth are serially homologous. Gene expression data from the mouse and some teleosts have shown that the gene families involved in pharyngeal odontogenesis are also involved in oral tooth formation, with the notable exception of the eux gene family. Here, we present a complete description of early odontogenesis in the medaka (Oryzias latipes), which has both oral and pharyngeal dentition. We show that oral and pharyngeal teeth share deep developmental similarities. In the medaka, like in the zebrafish, eve1 is the only evx gene expressed during odontogenesis. In each forming tooth, regardless of its location, eve1 transcription is activated in the placode, then becomes restricted to the inner dental epithelium and is activated in the dental mesenchyme during early differentiation, and finally ceases at late differentiation. Thus eve1 expression is not specific to pharyngeal teeth development as was previously suggested. Because it permits direct comparisons between oral and pharyngeal teeth by molecular, development and functional studies, the medaka is an excellent model to develop further insights into the evolution of odontogenesis in gnathostomes. J. Exp. Zool. (Mol. Dev. Evol.) 308B:693- 708, 2007. (c) 2007 Wiley-Liss, Inc.