DETERMINATION OF PCB METABOLIC, EXCRETION, AND ACCUMULATION RATES FOR USE AS INDICATORS OF BIOLOGICAL RESPONSE AND RELATIVE RISK
DETERMINATION OF PCB METABOLIC, EXCRETION, AND ACCUMULATION RATES FOR USE AS INDICATORS OF BIOLOGICAL RESPONSE AND RELATIVE RISK
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DOI：
10.1021/es00062a013
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发表时间：
1994-12-01
影响因子：
11.4
通讯作者：
BROWN, JF
中科院分区：
文献类型：
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作者：
BROWN, JF
新的和旧的动力学和色谱数据被用来计算，为146多氯联苯同源物，代谢的相对速率P4501 A和P4502 B类细胞色素和相对人体积累后70年的剂量[RHA（70）值]在正常和chloracnegene的人。 这些结果允许建立结构-活性关系，检测作为次要代谢途径的脱氯，表征代谢反应的种间差异（例如，P4501 A诱导），并合理化的多氯联苯之间的差异，在慢性毒性。 他们还指出，对于环境中的多氯联苯混合物，现在容易计算的RHA（70）值应能提供一种更好的相对慢性健康风险的衡量标准，而且在评估生物修复过程中应特别有用。
New and old kinetic and chromatographic data were used to calculate, for 146 PCB congeners, the relative rates of metabolism by both P4501A- and P4502B-like cytochromes and the relative human accumulations after 70-yr dosing [RHA(70) values] in both normal and chloracnegenic persons. These results permitted establishment of structure-activity relationships, detection of dechlorination as a minor metabolic pathway, characterization of inter-species differences in metabolic response (e.g., P4501A induction), and rationalization of inter-Aroclor differences in chronic toxicity. They also indicated that for environmental PCB mixtures the now readily calculable RHA(70) values should provide an improved measure of relative chronic health risk, and one that should be particularly useful in the evaluation of bioremediation processes.