Peripubertal anxiety profile can predict predisposition to spatial memory impairments following chronic stress
Peripubertal anxiety profile can predict predisposition to spatial memory impairments following chronic stress
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DOI：
10.1016/j.bbr.2005.08.006
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发表时间：
2006-01-30
影响因子：
2.7
通讯作者：
Conrad, CD
中科院分区：
文献类型：
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作者：
Bellani, R;Luecken, LJ;Conrad, CD
我们测试了青春期焦虑水平可以预测慢性应激对海马区依赖的空间记忆的有害影响的假设。青春期雄性SD大鼠(43日龄)的焦虑水平以开阔场地和高架+迷宫为特征，然后从青年时期(75d)开始持续6h/d/21d的慢性束缚应激。慢性应激治疗后，采用两种不同难度水平(4h：慢性应激后1d；1min：慢性应激后2d)对大鼠进行空间Y迷宫测试。正如预期的那样，在难度较低的1分钟Y形迷宫中，所有组都表现出完整的空间记忆。然而，在4h的Y迷宫中，慢性应激高焦虑大鼠表现出空间记忆受损，而慢性应激低焦虑和对照(低焦虑和高焦虑)大鼠表现出完整的空间记忆。此外，在慢性应激结束一个月后，高焦虑组的基础皮质酮水平显著高于低焦虑组(对照组和应激组)。这些结果表明，青春期焦虑和慢性应激交互作用影响成年后的海马区依赖的空间记忆。(C)2005 Elsevier B.V.保留所有权利。
We tested the hypothesis that peripubertal anxiety levels are predictive of the detrimental effects of chronic stress on hippocampal-dependent spatial memory. The anxiety levels of peripubertal male Sprague-Dawley rats (43 days old) were characterized using open field and elevated plus mazes, followed by chronic restraint stress for 6 h/day/21 days beginning in young adulthood (75 days). Following chronic stress treatment, rats were tested on the spatial Y-maze using two inter-trial interval levels of difficulty (4 h: 1 day post-chronic stress; 1 min: 2 days post-chronic stress). As expected, all groups displayed intact spatial memory in the less difficult 1 min version of the Y-maze. However, in the 4h version of the Y-maze, chronically stressed high anxiety rats showed impaired spatial memory, while chronically stressed low anxiety and control (low and high anxiety) rats displayed intact spatial memory. Moreover, a month after chronic stress ended, high anxiety rats had significantly higher basal corticosterone levels than low anxiety rats (control and stress). These results indicate that peripubertal anxiety and chronic stress interact to influence hippocampal-dependent spatial memory in adulthood. (c) 2005 Elsevier B.V. All rights reserved.