Effects of exercise training on antitumor efficacy of doxorubicin in MDA-MB-231 breast cancer xenografts
Effects of exercise training on antitumor efficacy of doxorubicin in MDA-MB-231 breast cancer xenografts
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DOI：
10.1158/1078-0432.ccr-05-0844
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发表时间：
2005-09-15
影响因子：
11.5
通讯作者：
Mackey, JR
中科院分区：
文献类型：
--
作者：
Jones, LW;Eves, ND;Mackey, JR
目的：运动作为一种有益的辅助疗法，可以维持或提高接受辅助化疗的乳腺癌患者的生活质量。实验设计：将无胸腺雌性小鼠移植MDA-MB-231乳腺异种移植物，并随机分配到四组之一（每组n = 21）：（a）对照，（B）仅运动，（c）仅多柔比星，或（d）运动+多柔比星。运动组进行递增负荷跑台运动，以18 m/min的速度进行0%的运动，持续45 min，5 d/wk，共8周。结果：与对照组相比，单纯阿霉素组和运动+阿霉素组的肿瘤生长延迟时间明显延长（中位数分别为42与25天，P = 0.0082; 36与25天，P = 0.029）和仅运动组（中位数分别为42天与25天，P = 0.029; 36天与25天，P = 0.080）。有没有显着差异之间的阿霉素，只有运动+阿霉素组（中位数42与36天，P = 0.33），表明中等强度的运动并没有显着影响阿霉素诱导的肿瘤生长delay.Conclusion：这些研究是必不可少的，以充分了解运动的安全性和应用作为癌症控制的支持性干预措施。
Purpose: Exercise is becoming readily accepted as a beneficial adjunct therapy to maintain or enhance quality of life in breast cancer patients undergoing adjuvant chemotherapy. An essential precursor to these studies is to investigate whether exercise modulates the antitumor efficacy of chemotherapeutic agents.Experimental Design: Athymic female mice were transplanted with MDA-MB-231 breast xenografts and randomly assigned to one of four groups (n = 21 per group): (a) control, (b) exercise-only, (c) doxorubicin-only, or (d) exercise + doxorubicin. Exercise groups performed progressive treadmill running up to 18 m/min at 0% grade for 45 minutes, 5 d/wk for 8 weeks.Results: Tumor growth delay was significantly longer in the doxorubicin-only and exercise + doxorubicin groups compared with the control (median 42 versus 25 days, P = 0.0082; 36 versus 25 days, P = 0.029, respectively) and exercise-only groups (median 42 versus 25 days, P = 0.029; 36 versus 25 days, P = 0.080, respectively). There was no significant difference between the doxorubicin-only and exercise + doxorubicin groups (median 42 versus 36 days, P = 0.33), suggesting that moderate intensity exercise does not significantly influence doxorubicin-induced tumor growth delay.Conclusion: These studies are essential to fully understand the safety and application of exercise as a supportive intervention in cancer control.