Multiple Mycobacterium tuberculosis strains in early cultures from patients in a high-incidence community setting
Multiple Mycobacterium tuberculosis strains in early cultures from patients in a high-incidence community setting
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DOI：
10.1128/jcm.40.8.2750-2754.2002
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发表时间：
2002-08-01
影响因子：
9.4
通讯作者：
van Helden, PD
中科院分区：
文献类型：
--
作者：
Richardson, M;Carroll, NM;van Helden, PD
在一项正在进行的分子流行病学研究中，纳入了来自高发社区的首次肺结核的人类免疫缺陷病毒阴性患者。结核分枝杆菌菌株鉴定的限制性片段长度多态性分析与两个指纹探针。在131例患者中，3例（2.3%）在一次或两次连续培养中显示出菌株混合。本研究进一步调查了这些由多个M引起的疾病。结核菌株的分子流行病学背景下的研究设置。
In an ongoing molecular epidemiology study, human immunodeficiency virus-negative patients with first-time pulmonary tuberculosis from a high-incidence community were enrolled. Mycobacterium tuberculosis strains were identified by restriction fragment length polymorphism analysis with two fingerprinting probes. Of 131 patients, 3 (2.3%) were shown to have a mixture of strains in one or two of their serial cultures. This study further investigated these cases with disease caused by multiple M. tuberculosis strains in the context of the molecular epidemiology of the study setting.