Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism
Role of human aldehyde dehydrogenases in endobiotic and xenobiotic metabolism
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DOI：
10.1081/dmr-120034001
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发表时间：
2004-05-01
影响因子：
5.9
通讯作者：
Estey, T
中科院分区：
文献类型：
--
作者：
Vasiliou, V;Pappa, A;Estey, T
人类基因组包含至少17个醛脱氢酶（ALDH）超家族成员的基因。这些基因编码依赖于NAD(P)（+）的酶，这些酶可以将多种醛氧化为相应的羧酸。醛是一种高活性分子，是广泛参与生理、生物和药理学过程的中间体或产物。醛是在维甲酸生物合成和氨基酸、脂类、碳水化合物和药物代谢过程中产生的。几个ALDH基因的突变是先天性代谢错误的分子基础，并有助于环境诱导的疾病。
The human genome contains at least 17 genes that are members of the aldehyde dehydrogenase (ALDH) superfamily. These genes encode NAD(P)(+)-dependent enzymes that oxidize a wide range of aldehydes to their corresponding carboxylic acids. Aldehydes are highly reactive molecules that are intermediates or products involved in a broad spectrum of physiologic, biologic, and pharmacologic processes. Aldehydes are generated during retinoic acid biosynthesis and the metabolism of amino acids, lipids, carbohydrates, and drugs. Mutations in several ALDH genes are the molecular basis of inborn errors of metabolism and contribute to environmentally induced diseases.