Estimations of intrinsic and extrinsic noise in models of nonlinear genetic networks
Estimations of intrinsic and extrinsic noise in models of nonlinear genetic networks
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DOI：
10.1063/1.2211787
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发表时间：
2006-06-01
期刊：
影响因子：
2.9
通讯作者：
Kaern, Mads
中科院分区：
文献类型：
--
作者：
Scott, Matthew;Ingalls, Brian;Kaern, Mads
我们讨论了两种可以用来估计内部和外部变化对非线性系统的影响的方法，并通过比较两个不同设计的实验实现的振荡遗传网络来证明它们的有效性。这些方法可以快速估计内在和外在噪声，并在分析自然遗传网络和构建合成基因调控系统时被证明是有用的。
We discuss two methods that can be used to estimate the impact of internal and external variability on nonlinear systems, and demonstrate their utility by comparing two experimentally implemented oscillatory genetic networks with different designs. The methods allow for rapid estimations of intrinsic and extrinsic noise and should prove useful in the analysis of natural genetic networks and when constructing synthetic gene regulatory systems.