Single-Scan Selective Excitation of Individual NMR Signals in Overlapping Multiplets.
Single-Scan Selective Excitation of Individual NMR Signals in Overlapping Multiplets.
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DOI：
10.1002/anie.202011642
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发表时间：
2021-01-11
期刊：
影响因子：
--
通讯作者：
Adams RW
中科院分区：
文献类型：
--
作者：
Kiraly P;Kern N;Plesniak MP;Nilsson M;Procter DJ;Morris GA;Adams RW
二维核磁共振是一种非常强大的结构工具，但它非常耗时。在一维实验中通过选择性激发来瞄准单个化学基团可以更快地提供所需的信息。然而，一个主要问题是质子核磁共振谱经常广泛重叠，因此实际上只有少数位点可以被选择性激发。在这里，我们使用快速单扫描方法克服了这个问题，该方法允许选择性激发单个质子多重峰的信号，即使它与其他多重峰严重重叠。该方法的优点在选择性 1D NOESY 实验中得到了说明，这是通过 NMR 明确确定相对构型的最有效方法。这里提出的新方法有可能显着扩大选择性激发的适用性，并释放其在许多其他实验中的真正潜力。单次扫描中重叠多重峰的选择性激发拓宽了一维选择性核磁共振实验的适用性。
2D NMR is an immensely powerful structural tool but it is time‐consuming. Targeting individual chemical groups by selective excitation in a 1D experiment can give the information required far more quickly. A major problem, however, is that proton NMR spectra are often extensively overlapped, so that in practice only a minority of sites can be selectively excited. Here we overcome that problem using a fast, single‐scan method that allows selective excitation of the signals of a single proton multiplet even where it is severely overlapped by other multiplets. The advantages of the method are illustrated in a selective 1D NOESY experiment, the most efficient way to determine relative configuration unambiguously by NMR. The new approach presented here has the potential to broaden significantly the applicability of selective excitation and unlock its real potential for many other experiments. Selective excitation of overlapped multiplets in a single scan broadens the applicability of 1D selective NMR experiments.
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影响因子：
15
作者：
BOULAT, B;KONRAT, R;BODENHAUSEN, G
通讯作者：
BODENHAUSEN, G
影响因子：
21.8
作者：
Kern, Nicolas;Plesniak, Mateusz P.;Procter, David J.
通讯作者：
Procter, David J.
影响因子：
2.2
作者：
Hu, HT;Bradley, SA;Krishnamurthy, K
通讯作者：
Krishnamurthy, K
影响因子：
2.2
作者：
Robinson, PT;Pham, TN;Uhrín, D
通讯作者：
Uhrín, D
影响因子：
3.6
作者：
Savage, Scott;McClory, Andrew;Gosselin, Francis
通讯作者：
Gosselin, Francis