Mechanical modes of 'amoeboid' cell migration
Mechanical modes of 'amoeboid' cell migration
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DOI：
10.1016/j.ceb.2009.05.003
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发表时间：
2009-10-01
影响因子：
7.5
通讯作者：
Sixt, Michael
中科院分区：
文献类型：
--
作者：
Laemmermann, Tim;Sixt, Michael
形态学术语“变形虫”迁移包含许多相当独特的细胞运动生物物理模式，范围从起泡运动到完全基于肌动蛋白聚合的滑动。在这里，我们讨论导致不同变形虫表型的力产生和力传导的不同原理。我们认为，改变肌动蛋白突出、肌动球蛋白收缩和细胞外基质粘附之间的平衡可以解释变形虫运动的不同模式，而起泡和滑动只是一种常见迁移策略的极端变体。根据细胞类型、生理条件或实验操作，变形虫细胞可以采用不同的变形虫迁移机械模式。
The morphological term 'amoeboid' migration subsumes a number of rather distinct biophysical modes of cellular locomotion that range from blebbing motility to entirely actin-polymerization-based gliding. Here, we discuss the diverse principles of force generation and force transduction that lead to the distinct amoeboid phenotypes. We argue that shifting the balance between actin protrusion, actomyosin contraction, and adhesion to the extracellular substrate can explain the different modes of amoeboid movement and that blebbing and gliding are barely extreme variants of one common migration strategy. Depending on the cell type, physiological conditions or experimental manipulation, amoeboid cells can adopt the distinct mechanical modes of amoeboid migration.