Clinical aspects of 27 cases of neosporosis in dogs
Clinical aspects of 27 cases of neosporosis in dogs
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DOI：
10.1136/vr.139.18.439
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发表时间：
1996-11-02
影响因子：
2.2
通讯作者：
Trees, AJ
中科院分区：
文献类型：
--
作者：
Barber, JS;Trees, AJ
本文报道了27例欧洲犬新孢子虫病，经免疫组化、电镜观察，或对治疗有良好反应的犬的临床症状，以及对犬新孢子虫抗体的存在而非对弓形虫抗体的存在，证实了该病的发生。两种性别均受影响，在大多数情况下同窝仔保持正常，21例病例最初出现后肢轻瘫或共济失调，其中肌肉萎缩是最一致的临床体征，约一半病例出现僵硬性过伸，厌食症和发热罕见。其他临床症状包括前肢共济失调、头部震颤伴四肢轻瘫和心肌炎引起的突然虚脱。20例采集血清标本的犬钩虫间接荧光抗体试验滴度≥ 1：800。如此高的滴度在健康犬中很少见，强烈提示诊断为新孢子虫病。16只犬接受了克林霉素、增效磺胺类药物和/或乙胺嘧啶的适当抗原虫治疗; 10只犬完全或功能性恢复，在具有严重临床体征的超急性病例中以及治疗延迟时，恢复的可能性较小。
Twenty-seven cases of neosporosis in European dogs are described, The disease was confirmed by immunohistochemistry, electron microscopy, or a favourable response to treatment in the dogs with appropriate clinical signs, and by the presence of antibodies to Neospora caninum but not to Toxoplasma gondii, The affected dogs were two days to seven years old, and of 13 different breeds. Both sexes were affected and in most cases littermates remained normal, Twenty-one cases had an initial hindlimb paresis or ataxia, in which muscle atrophy was the most consistent clinical sign, Rigid hyperextension developed in approximately half of the cases, Anorexia and pyrex-in were rare. Other clinical signs included forelimb ataxia, head tremors with tetraparesis and sudden collapse due to myocarditis, Titres of greater than or equal to 1:800 in the N caninum indirect fluorescent antibody test were detected in the 20 cases from which serum samples were taken. Such high titres are rare in healthy dogs and strongly suggest a diagnosis of neosporosis. Sixteen of the dogs received appropriate antiprotozoal treatment with clindamycin, potentiated sulphonamides and/or pyrimethamine; 10 made a full or functional recovery, Recovery was less likely in peracute cases with severe clinical signs, and when the treatment was delayed.