Anti-stiffness effect of apocynin in deoxycorticosterone acetate-salt hypertensive rats via inhibition of oxidative stress
Anti-stiffness effect of apocynin in deoxycorticosterone acetate-salt hypertensive rats via inhibition of oxidative stress
复制标题
罗布麻宁通过抑制氧化应激对醋酸脱氧皮质酮盐高血压大鼠的抗僵硬作用
DOI：
10.1038/hr.2012.170
复制
发表时间：
2013-04-01
影响因子：
5.4
通讯作者：
Gao, Ping-Jin
中科院分区：
文献类型：
--
作者：
Chen, Qi-Zhi;Han, Wei-Qing;Gao, Ping-Jin
本研究旨在确定烟酰胺腺嘌呤二核苷酸磷酸氧化酶抑制剂——夹竹桃麻素是否会通过传导动脉的结构和功能变化来减轻盐敏感性高血压大鼠的动脉僵硬度。我们发现，与假对照组相比，醋酸脱氧皮质酮 - 盐诱导的高血压（DSH）大鼠的尾部血压显著升高（P
This study sought to determine if apocynin, a nicotinamide adenine dinucleotide phosphate oxidase inhibitor, would attenuate arterial stiffness in salt-sensitive hypertensive rats via structural and functional changes in conduit arteries. We showed that tail blood pressure was significantly higher in deoxycorticosterone acetate-salt-induced hypertensive (DSH) rats compared with the sham control group (P< 0.01). Morphological analysis and biochemical assay showed that large arteries in DSH rats underwent significant remodeling including increased medial thickness in carotid arteries compared with the control rats (194.25±5.66 vs. 120.48±7.93 μm, P< 0.05) and increased collagen deposition in thoracic aorta (1.03±0.09 vs. 0.85±0.04 mg cm− 1, P< 0.05). These changes were associated with increases in reactive oxygen species (ROS) level and increased thoracic aortic stiffness compared with the control rats (6.21±0.79 m s− 1 vs. 4.64±0.59 m s− 1, P< 0.01). Treatment with apocynin significantly prevented ROS increases and collagen deposition (0.84±0.04 vs. 1.03±0.09 mg cm− 1, P< 0.05), and reduced arterial stiffness as shown by decreased pulse wave velocity in the thoracic aorta (5.31±0.88 vs. 6.21±0.79 m s− 1, P< 0.01). Additionally, apocynin prevented carotid artery wall thickening (58.57±3.40 vs. 78.89±4.10 μm, P< 0.05). In conclusion we have shown that increased ROS level is associated with increased aortic stiffness, and deposition of collagen in the aortic arterial wall in DSH rats. Apocynin prevented ROS increases and arterial stiffness in DSH rats. Antioxidant therapy may be a potential treatment of large arterial stiffness in salt-sensitive hypertension.