Mixing patterns and the spread of close-contact infectious diseases.
Mixing patterns and the spread of close-contact infectious diseases.
复制标题
DOI：
10.1186/1742-7622-3-10
复制
发表时间：
2006-08-14
影响因子：
2.3
通讯作者：
Mossong JR
中科院分区：
文献类型：
--
作者：
Edmunds WJ;Kafatos G;Wallinga J;Mossong JR
令人惊讶的是，人们对与麻疹、流感和脑膜炎球菌病等密切接触感染传播有关的人类混合模式知之甚少。这项研究的目的是估计个人建立的伙伴关系的数量，他们的稳定性和混合在多大程度上是相对于年龄的不确定性。我们定义了四个级别的假定风险事件，从偶然（没有交谈的身体接触）到亲密（性接触），并要求大学生志愿者记录他们在三个不同的日子里在这些级别接触的细节。我们发现，亲密接触在短时间内是稳定的，而没有证据表明与同一个人有重复的偶然接触。随着亲密程度的增加，接触也越来越具有吸引力。这些信息将有助于密切接触疾病模型的开发和参数化，并可能直接用于暴发调查。
Surprisingly little is known regarding the human mixing patterns relevant to the spread of close-contact infections, such as measles, influenza and meningococcal disease. This study aims to estimate the number of partnerships that individuals make, their stability and the degree to which mixing is assortative with respect to age. We defined four levels of putative at-risk events from casual (physical contact without conversation) to intimate (contact of a sexual nature), and asked university student volunteers to record details on those they contacted at these levels on three separate days. We found that intimate contacts are stable over short time periods whereas there was no evidence of repeat casual contacts with the same individuals. The contacts were increasingly assortative as intimacy increased. Such information will aid the development and parameterisation of models of close contact diseases, and may have direct use in outbreak investigations.