Carboplatin dosing: gender bias and inaccurate estimates of glomerular filtration rate
Carboplatin dosing: gender bias and inaccurate estimates of glomerular filtration rate
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DOI：
10.1016/s0959-8049(00)00455-x
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发表时间：
2002-01-01
影响因子：
8.4
通讯作者：
Webster, LK
中科院分区：
文献类型：
--
作者：
Dooley, MJ;Poole, SG;Webster, LK
目的是比较使用Calvert公式和Chatelut公式计算的卡铂剂量，以及使用Cockcroft和Gault公式或Jelliffe公式（使用GFR的非同位素估计进行修改）计算的剂量。用于公式比较。计算的剂量目标AUC为7 mg/ml·min。与Calvert公式得出的剂量相比，使用Chatelut公式计算的122名成年癌症患者的剂量对于男性显著较高，而对于女性显著较低。雄性和雌性计算的每kg剂量之间存在统计学显著差异（P < 0.0001）。用Cockcroft和Gault公式和Jelliffe公式替代肾功能测量值计算的剂量平均百分比差异为-8%（标准差（S.D.）17%）和-14%（S.D. 16%）。分别在推荐用于常规临床应用之前，需要对Chatelut公式进行进一步的前瞻性评价。(C)2002爱思唯尔科技有限公司。保留所有权利。
The aim as to compare doses of carboplatin calculated using the Calvert formula and Chatelut formula and also to compare doses calculated using Calvert formula, modified with non-isotopic estimation of GFR, using the Cockcroft and Gault formula or the Jelliffe formula. For formulae comparison. the doses were calculated to target an AUC of 7 mg ml.min. When compared with the dose derived from the Calvert formula, the doses calculated in 122 adult cancer patients using the Chatelut formula were significantly higher for males and significantly lower for females. There was a statistically significant difference between the dose per kg calculated for males and females (P < 0.0001). The mean percentage difference in dose calculated with substituted measures of renal function with the Cockcroft and Gault formula and Jelliffe formula was -8% (standard deviation (S.D.) 17%) and -14% (S.D. 16%). respectively. Further prospective evaluation of the Chatelut formula is required before it can be recommended for routine clinical application. (C) 2002 Elsevier Science Ltd. All rights reserved.