Docosahexaenoic Acid Is an Independent Predictor of All-Cause Mortality in Hemodialysis Patients
Docosahexaenoic Acid Is an Independent Predictor of All-Cause Mortality in Hemodialysis Patients
复制标题
DOI：
10.1159/000322952
复制
发表时间：
2011-01-01
影响因子：
4.2
通讯作者：
Hamazaki, Tomohito
中科院分区：
文献类型：
--
作者：
Hamazaki, Kei;Terashima, Yoshihiro;Hamazaki, Tomohito
背景资料：膳食中的n-3多不饱和脂肪酸（PUFA）、二十二碳六烯酸（DHA）和二十碳五烯酸已被证明可降低心血管死亡率。血液透析（HD）患者的心血管疾病死亡率非常高。食用鱼类可降低HD患者的全因死亡率。此外，n-3 PUFA，特别是红细胞（RBC）中的DHA水平，与HD患者的动脉硬化有关。本研究的目的是在一项前瞻性队列研究中确定红细胞中的DHA水平是否能预测HD患者的死亡率。方法：对176例接受HD治疗的患者（64.1 ± 12.0（平均值± SD）岁，96例男性和80例女性）进行了研究。用气相色谱法分析红细胞脂肪酸组成。结果：在5年的研究期间，发生了54例死亡。调整10个混杂因素后，与DHA最低三分位数的患者（<7.2%，21例死亡）相比，DHA最高三分位数的HD患者（> 8.1%，15例死亡）的全因死亡率的考克斯风险比为0.43（95% CI 0.21-0.88）。结论：研究结果表明，红细胞中的DHA水平可能是HD患者全因死亡率的独立预测因子。版权所有（C）2010 S. Karger AG，巴塞尔
Background: Dietary n-3 polyunsaturated fatty acids (PUFAs), docosahexaenoic acid (DHA) and eicosapentaenoic acid have been shown to reduce cardiovascular mortality. Patients on hemodialysis (HD) have a very high mortality from cardiovascular disease. Fish consumption reduces all-cause mortality in patients on HD. Moreover, n-3 PUFAs, especially DHA levels in red blood cells (RBCs), are associated with arteriosclerosis in patients on HD. The aim of this study was to determine whether DHA levels in RBCs predict the mortality of patients on HD in a prospective cohort study. Method:;: A cohort of 176 patients (64.1 +/- 12.0 (mean +/- SD) years of age, 96 men and 80 women) under HD treatment was studied. The fatty acid composition of their RBCs was analyzed by gas chromatography. Results: During the study period of 5 years, 54 deaths occurred. After adjustment for 10 confounding factors, the Cox hazard ratio of all-cause mortality of the patients on HD in the highest DHA tertile (> 8.1%, 15 deaths) was 0.43 (95% Cl 0.21-0.88) compared with those patients in the lowest DHA tertile (< 7.2%, 21 deaths). Conclusion: The findings suggest that the level of DHA in RBCs could be an independent predictor of all-cause mortality in patients on HD. Copyright (C) 2010 S. Karger AG, Basel