Impact of Medical Qigong on quality of life, fatigue, mood and inflammation in cancer patients: a randomized controlled trial
Impact of Medical Qigong on quality of life, fatigue, mood and inflammation in cancer patients: a randomized controlled trial
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DOI：
10.1093/annonc/mdp479
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发表时间：
2010-03-01
影响因子：
50.5
通讯作者：
Rosenthal, D.
中科院分区：
文献类型：
--
作者：
Oh, B.;Butow, P.;Rosenthal, D.
背景：大量的癌症患者使用辅助药物治疗，即使没有支持性的证据基础。本研究旨在通过一项随机对照试验，评价医学气功（MQ）与常规护理相比对癌症患者生活质量（QOL）的改善。患者和方法：162名患有各种癌症的患者被招募。生活质量和疲劳分别用《癌症治疗功能评定-疲劳》和《癌症治疗功能评定-疲劳》测量，情绪状态用《情绪状态概况》测量。连续监测炎症标志物血清c反应蛋白（CRP）。结果：回归分析显示，在控制基线变量后，MQ组总体生活质量（t(144) = 25.761, P < 0.001）、疲劳（t(153) = 25.621, P < 0.001）、情绪障碍（t(122) = 2.346, P = 0.021）、炎症反应（CRP） （t(99) = 2.042, P < 0.044）均较常规护理显著改善。结论：本研究提示MQ可改善肿瘤患者的整体生活质量和情绪状态，减少治疗的特定副作用。从长远来看，它还可以减少炎症，从而对身体有益。
Background: Substantial numbers of cancer patients use complementary medicine therapies, even without a supportive evidence base. This study aimed to evaluate in a randomized controlled trial, the use of Medical Qigong (MQ) compared with usual care to improve the quality of life (QOL) of cancer patients.Patients and methods: One hundred and sixty-two patients with a range of cancers were recruited. QOL and fatigue were measured by Functional Assessment of Cancer Therapy-General and Functional Assessment of Cancer Therapy-Fatigue, respectively, and mood status by Profile of Mood State. The inflammatory marker serum C-reactive protein (CRP) was monitored serially.Results: Regression analysis indicated that the MQ group significantly improved overall QOL (t(144) = 25.761, P < 0.001), fatigue (t(153) = 25.621, P < 0.001), mood disturbance (t(122) = 2.346, P = 0.021) and inflammation (CRP) (t(99) = 2.042, P < 0.044) compared with usual care after controlling for baseline variables.Conclusions: This study indicates that MQ can improve cancer patients' overall QOL and mood status and reduce specific side-effects of treatment. It may also produce physical benefits in the long term through reduced inflammation.