Chemical synaptic activity modulates nearby electrical synapses
Chemical synaptic activity modulates nearby electrical synapses
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DOI：
10.1073/pnas.0734299100
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发表时间：
2003-04-15
影响因子：
11.1
通讯作者：
Pereda, AE
中科院分区：
文献类型：
--
作者：
Smith, M;Pereda, AE
大多数电耦合神经元也接受大量的化学突触输入。化学突触被认为是高度动态的，而缝隙连接介导的电传递通常被认为是不太可修改和可变的。通过使用突触前和突触后的同步记录，我们在单个混合的电和化学突触上证明了快速的化学传递与同一末端的缝隙连接相互作用，以调节它们的电导。这种局部性的相互作用是活动依赖的，可以解释终止于Mauthner细胞外侧树突的听觉传入突触的电耦合强度的巨大差异。因此，化学突触和电突触之间的相互作用可以调节电耦合的程度，使给定的神经元有可能独立地修改不同电突触与其邻居的耦合。
Most electrically coupled neurons also receive numerous chemical synaptic inputs. Whereas chemical synapses are known to be highly dynamic, gap junction-mediated electrical transmission often is considered to be less modifiable and variable. By using simultaneous pre- and postsynaptic recordings, we demonstrate at single mixed electrical and chemical synapses that fast chemical transmission interacts with gap junctions within the same ending to regulate their conductance. Such localized interaction is activity-dependent and could account for the large variation in strength of electrical coupling at auditory afferent synapses terminating on the Mauthner cell lateral dendrite. Thus, interactions between chemical and electrical synapses can regulate the degree of electrical coupling, making it possible for a given neuron to independently modify coupling at different electrical synapses with its neighbors.