Apical constriction: a cell shape change that can drive morphogenesis.
Apical constriction: a cell shape change that can drive morphogenesis.
复制标题
DOI：
10.1016/j.ydbio.2009.09.009
复制
发表时间：
2010-05-01
影响因子：
2.7
通讯作者：
Goldstein, Bob
中科院分区：
文献类型：
--
作者：
Sawyer, Jacob M.;Harrell, Jessica R.;Shemer, Gidi;Sullivan-Brown, Jessica;Roh-Johnson, Minna;Goldstein, Bob
生物学家早就认识到，细胞片层的剧烈弯曲可能是由细胞顶侧的适度收缩驱动的。像这样的细胞形状变化和组织运动是许多形态发生运动的核心，这些运动在发育过程中塑造了动物的形态，驱动了原肠胚形成、管形成和神经胚形成等过程。这种细胞形状变化的机制必须整合发育模式信息，以便在空间和时间上控制力的产生--这些问题涉及细胞和发育生物学以及出生缺陷研究的基本方面。发展模式如何调节力产生机制，这些机制在发展中扮演什么角色？研究了果蝇、C.线虫、海胆、非洲爪蟾、小鸡和老鼠已经开始阐明这些问题。在这里，我们回顾这一努力，探索顶端收缩的机制的多样性，顶端收缩在发展中发挥的作用的多样性，以及比较系统中出现的共同主题。
Biologists have long recognized that dramatic bending of a cell sheet may be driven by even modest shrinking of the apical sides of cells. Cell shape changes and tissue movements like these are at the core of many of the morphogenetic movements that shape animal form during development, driving processes such as gastrulation, tube formation and neurulation. The mechanisms of such cell shape changes must integrate developmental patterning information in order to spatially and temporally control force production -- issues that touch on fundamental aspects of both cell and developmental biology and on birth defects research. How does developmental patterning regulate force-producing mechanisms, and what roles do such mechanisms play in development? Work on apical constriction from multiple systems including Drosophila, C. elegans, sea urchin, Xenopus, chick and mouse has begun to illuminate these issues. Here, we review this effort to explore the diversity of mechanisms of apical constriction, the diversity of roles that apical constriction plays in development, and the common themes that emerge from comparing systems.
登录
查看更多内容
影响因子：
64.5
作者：
Drees, F;Pokutta, S;Weis, WI
通讯作者：
Weis, WI
影响因子：
4.8
作者：
Dietz, Megan L.;Bernaciak, Teresa M.;Hildebrand, Jeffrey D.
通讯作者：
Hildebrand, Jeffrey D.
影响因子：
4
作者：
Chung, SeYeon;Andrew, Deborah J.
通讯作者：
Andrew, Deborah J.
影响因子：
2.7
作者：
BURNSIDE, B
通讯作者：
BURNSIDE, B
影响因子：
--
作者：
ALVAREZ, IS;NAVASCUES, J
通讯作者：
NAVASCUES, J