Genetic and biochemical analysis of non-vesicular lipid traffic.
Genetic and biochemical analysis of non-vesicular lipid traffic.
复制标题
DOI：
10.1146/annurev.biochem.78.081307.112144
复制
发表时间：
2009-06
影响因子：
16.6
通讯作者：
D. Voelker
中科院分区：
文献类型：
--
作者：
D. Voelker
膜内和膜间强大的脂质运输对于细胞生长和膜生物发生至关重要。许多这些转运反应是通过非囊泡途径发生的，这些过程的遗传和生化细节现在开始出现。膜内脂质转运反应利用 P 型 ATP 酶、ABC 转运蛋白、扰乱酶和 Niemann-Pick C 型 (NPC) 家族蛋白。膜内过程调节膜脂质不对称的建立和消除、甾醇和磷脂的细胞流入和流出以及溶酶体沉积的脂质的流出。膜间脂质转运过程在膜生物发生、甾醇封存和类固醇激素形成中发挥重要作用。可溶性脂质载体和膜结合脂质转运复合物的作用，以及它们的靶向和组装的调节机制，现在变得越来越明显。对这些系统细节的阐明为细胞内脂质运输的调节提供了新的视角。
Robust lipid traffic within and among membranes is essential for cell growth and membrane biogenesis. Many of these transport reactions occur by nonvesicular pathways, and the genetic and biochemical details of these processes are now beginning to emerge. Intramembrane lipid transport reactions utilize P-type ATPases, ABC transporters, scramblases, and Niemann-Pick type C (NPC) family proteins. The intramembrane processes regulate the establishment and elimination of membrane lipid asymmetry, the cellular influx and efflux of sterols and phospholipids, and the egress of lysosomally deposited lipids. The intermembrane lipid transport processes play important roles in membrane biogenesis, sterol sequestration, and steroid hormone formation. The roles of soluble lipid carriers and membrane-bound lipid-transporting complexes, as well as the mechanisms for regulation of their targeting and assembly, are now becoming apparent. Elucidation of the details of these systems is providing new perspectives on the regulation of lipid traffic within cells.