What women with ovarian cancer think and know about genetic testing
What women with ovarian cancer think and know about genetic testing
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DOI：
10.1016/j.ygyno.2008.06.016
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发表时间：
2008-10-01
影响因子：
4.7
通讯作者：
Lu, Karen H.
中科院分区：
文献类型：
--
作者：
Lacour, Robin A.;Daniels, Molly S.;Lu, Karen H.
目标.很少有卵巢癌患者接受乳腺癌和卵巢癌易感基因BRCA 1和BRCA 2的基因检测。随着BRCA基因导向治疗的前景，我们调查了卵巢癌患者对BRCA基因检测的认知和意愿。所有在癌症中心妇科中心和私人诊所就诊的卵巢癌患者都被要求完成一份关于接受BRCA检测的知识和意愿的匿名问卷。之前进行过基因检测的女性被要求不要参加。采用Fisher精确检验分析数据。237名卵巢癌患者自愿完成了问卷调查。55%（131/237）的参与者没有听说过BRCA检测。在白人受访者中，51%的人不知道BRCA检测，而西班牙裔受访者为70%，非洲裔受访者为88%（p=0.008）。意识与教育程度相关（p
Objectives. Few women with ovarian cancer undergo genetic testing for the Breast and Ovarian Cancer susceptibility genes, BRCA1 and BRCA2. With the prospect of BRCA-directed therapeutics, we investigated ovarian cancer patients' knowledge and willingness to undergo genetic testing.Methods. All ovarian cancer patients seen in the Gynecology Center of a cancer center and a private clinic were asked to complete an anonymous questionnaire regarding knowledge and willingness to undergo BRCA testing. Women who had prior genetic testing were asked not to participate. Data was analyzed using Fisher's exact test.Results. Two-hundred and thirty seven ovarian cancer patients voluntarily completed the questionnaire. Fifty-five percent (131/237) of participants had not heard of BRCA testing. Of Caucasian respondents, 51% were unaware of BRCA testing, compared to 70% of Hispanic and 88% of African American respondents (p=0.008). Awareness was correlated with education (p