VISUAL DYSFUNCTION IN PARKINSONS-DISEASE - LOSS IN SPATIOTEMPORAL CONTRAST SENSITIVITY
VISUAL DYSFUNCTION IN PARKINSONS-DISEASE - LOSS IN SPATIOTEMPORAL CONTRAST SENSITIVITY
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DOI：
10.1093/brain/110.6.1675
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发表时间：
1987-12-01
期刊：
影响因子：
14.5
通讯作者：
YAHR, M
中科院分区：
文献类型：
--
作者：
BODISWOLLNER, I;MARX, MS;YAHR, M
对99例帕金森病（PD）患者进行闪烁敏感性和空间对比敏感性（CS）检测。所有患者均接受多巴胺能药物治疗。在PD中观察到的特定灵敏度损失有：(1)闪烁灵敏度损失，在函数峰值（8 Hz）附近最为明显；(2)空间CS曲线峰值附近的损失，通常没有明显的低频衰减。几名受“开关”综合征影响的PD患者在“打开”和“关闭”阶段进行了测试，结果表明CS功能的开关与疾病的运动症状并行。这些数据表明，PD不仅影响视觉系统，而且多巴胺可能在人类视觉的感受野组织中发挥重要作用。
Flicker sensitivity and spatial contrast sensitivity (CS) were examined in a total of 99 patients with Parkinson's disease (PD). All patients were undergoing treatment with dopaminergic agents. Specific losses in sensitivity observed in PD were (1) a loss in flicker sensitivity which was most pronounced around the peak of the function (8 Hz) and (2) a loss near the peak of the spatial CS curve, often with no noticeable low frequency attenuation. Several PD patients affected by the ‘on-off ’ syndrome were tested in both ‘on’ and ‘off’ phases, and the results show that the CS function switches in parallel with motor symptoms of the disease. These data suggest that not only is the visual system affected in PD, but that dopamine may have an essential role in receptive field organization in human vision.