A biomechanical analysis of venous tissue in its normal and post-phlebitic conditions
A biomechanical analysis of venous tissue in its normal and post-phlebitic conditions
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DOI：
10.1016/j.jbiomech.2010.07.012
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发表时间：
2010-11-16
影响因子：
2.4
通讯作者：
Puttlitz, Christian M.
中科院分区：
文献类型：
--
作者：
McGilvray, Kirk C.;Sarkar, Rajabrata;Puttlitz, Christian M.
尽管对正常大鼠静脉壁的生物力学研究已有报道（Weizsacker, 1988; Plante, 2002），但尚未发表关于血栓形成对小鼠静脉组织的力学影响的研究。由于缺乏关于血栓溶解的机械后果的知识，通过双轴拉伸实验测量了小鼠腔静脉生物力学特性的明显血栓诱导变化。这些数据作为应变能函数（SEF）拟合和建模的输入（Gasser et al., 2006）。在代表非胶原性各向同性基质反应的结构系数方面，在健康组织和患病组织之间观察到统计差异。血栓形成后SEF系数的变化也被注意到，SEF系数描述了纤维的各向异性贡献。数据表明，腔静脉结扎导致基质和胶原纤维网络的结构改变。(C) 2010 Elsevier Ltd.版权所有。
Although biomechanical studies of the normal rat vein wall have been reported (Weizsacker, 1988; Plante, 2002), there are no published studies that have investigated the mechanical effects of thrombus formation on murine venous tissue. In response to the lack of knowledge concerning the mechanical consequences of thrombus resolution, distinct thrombus-induced changes in the biomechanical properties of the murine vena cava were measured via biaxial stretch experiments. These data served as input for strain energy function (SEF) fitting and modeling (Gasser et al., 2006). Statistical differences were observed between healthy and diseased tissue with respect to the structural coefficient that represents the response of the non-collagenous, isotropic ground substance. Alterations following thrombus formation were also noted for the SEF coefficient which describes the anisotropic contribution of the fibers. The data indicate ligation of the vena cava leads to structural alterations in the ground substance and collagen fiber network. (C) 2010 Elsevier Ltd. All rights reserved.