Bone Mineral Density and Bone Size in Men With Primary Osteoporosis and Vertebral Fractures
Bone Mineral Density and Bone Size in Men With Primary Osteoporosis and Vertebral Fractures
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DOI：
10.1007/s002239900462
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发表时间：
1998-05
影响因子：
4.2
通讯作者：
E. Vega;Gualterio Ghiringhelli;Carlos Mautalen;G. R. Valzacchi;H. Scaglia;C. Zylberstein
中科院分区：
文献类型：
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作者：
E. Vega;Gualterio Ghiringhelli;Carlos Mautalen;G. R. Valzacchi;H. Scaglia;C. Zylberstein
对38例男性原发性骨质疏松症和椎体骨折患者的腰椎、股骨近端和整个骨骼进行了骨密度(BMD)测定。与对照组相比，患者所有骨骼区域的骨密度均显著降低。腰椎的Z评分(−2.8±0.9)低于其他部位(P<；0.001)，除小腿(−2.5±1.1)外(P<0.0 5)。表明中轴骨上的骨丢失有更大的趋势。L2-L4投影面积(Cm2)为45.7±5.6对53.7±3.6(P<；0.001)，椎体宽度(Cm)为4.37±0.44对4.90±0.36(P<；0.001)。骨质疏松症患者的血清生化指标和睾酮水平与对照组相似。我们的结论是，与年龄匹配的对照组相比，患有椎体骨质疏松性骨折的男性患者的椎体骨密度和椎体尺寸都有所降低。因此，这些发现表明，在生长期结束时骨骼尺寸缩小或成年后骨膜增加失败可能是老年男性椎体骨折的发病机制之一。
The bone mineral density (BMD) at the lumbar spine, proximal femur, and total skeleton was evaluated in 38 men with primary osteoporosis and vertebral fractures. BMD of the patients was significantly reduced over all skeletal areas compared with controls. The Z-score of the lumbar spine (−2.8 ± 0.9) was less than that of the other areas (P< 0.001) except the legs (−2.5 ± 1.1) (p.n.s.) showing that bone loss had a tendency to be greater over the axial skeleton. Vertebral dimensions compared with age-matched controls were as follows: projected L2–L4 area (cm 2): 45.7 ± 5.6 versus 53.7 ± 3.6 (P< 0.001); vertebral width (cm): 4.37 ± 0.44 versus 4.90 ± 0.36 (P< 0.001). Serum biochemical parameters and testosterone levels were similar between osteoporotic and control men. We conclude that men with vertebral osteoporotic fractures have reduced vertebral BMD and vertebral dimensions compared with age-matched controls. Thus, these findings indicate that the achievement of a reduced bone size at the end of the growth period or a failure of periosteal increase during adult life is likely to contribute to the pathogenesis of the vertebral fractures observed in older men.