Supernatant protein factor in complex with RRR-alpha-tocopherylquinone: a link between oxidized Vitamin E and cholesterol biosynthesis.
Supernatant protein factor in complex with RRR-alpha-tocopherylquinone: a link between oxidized Vitamin E and cholesterol biosynthesis.
复制标题
与 RRR-α-生育醌复合物的上清蛋白因子：氧化维生素 E 和胆固醇生物合成之间的联系。
DOI：
10.1016/s0022-2836(03)00924-0
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发表时间：
2003
影响因子：
5.6
通讯作者：
U. Baumann
中科院分区：
文献类型：
--
作者：
A. Stocker;U. Baumann
The vast majority of monomeric lipid transport in nature is performed by lipid-specific protein carriers. This class of proteins can enclose cognate lipid molecules in a hydrophobic cavity and transport them across the aqueous environment. Supernatant protein factor (SPF) is an enigmatic representative of monomeric lipid transporters belonging to the SEC14 family. SPF stimulates squalene epoxidation, a downstream step of the cholesterol biosynthetic pathway, by an unknown mechanism. Here, we present the three-dimensional crystal structure of human SPF in complex with RRR-α-tocopherylquinone, the major physiological oxidation product of RRR-α-tocopherol, at a resolution of 1.95Å. The structure of the complex reveals how SPF sequesters RRR-α-tocopherylquinone (RRR-α-TQ) in its protein body and permits a comparison with the recently solved structure of human α-tocopherol transfer protein (α-TTP) in complex with RRR-α-tocopherol. Recent findings have shown that RRR-α-TQ is reduced in vivo to RRR-α-TQH2, the latter has been suggested to protect low-density lipoprotein (LDL) particles from oxidation. Hence, the antioxidant function of the redox couple RRR-α-TQ/RRR-α-TQH2in blocking LDL oxidation may reduce cellular cholesterol uptake and thus explain how SPF upregulates cholesterol synthesis.
区分有和没有脂蛋白代谢遗传异常的人类维生素 E 的形式。
影响因子：
6.5
作者：
Traber,MG;Burton,GW;Hughes,L;Ingold,KU;Hidaka,H;Malloy,M;Kane,J;Hyams,J;Kayden,HJ
通讯作者：
Kayden,HJ