Common and distinct networks for self-referential and social stimulus processing in the human brain
Common and distinct networks for self-referential and social stimulus processing in the human brain
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DOI：
10.1007/s00429-015-1113-9
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发表时间：
2016-09-01
影响因子：
3.1
通讯作者：
Bermpohl, Felix
中科院分区：
文献类型：
--
作者：
Herold, Dorrit;Spengler, Stephanie;Bermpohl, Felix
自我参照加工是一种复杂的认知功能，涉及一系列内隐和外显加工，使对其独特神经信号的研究变得复杂。本研究探讨了自我参照和社会刺激加工的功能重叠性和分离性。我们在一个功能磁共振成像实验中结合了一个已建立的外显自我参照加工范式和一个内隐社会刺激加工范式，以确定在一项研究中自我关联和社会加工的神经效应。在眶额皮质和楔前叶的中间部分发现重叠激活。被判断为自我参照的刺激会激活后扣带皮层、腹内侧前额叶皮层（延伸到前扣带皮层和眶额皮层）、背内侧前额叶皮层、腹侧和背外侧前额叶皮层、左颞下回和枕叶皮层。社会处理特别涉及后楔前叶和双侧颞顶叶交界处。综上所述，我们的数据不仅显示了内侧前额叶皮层和内侧顶叶皮层的共同网络，而且还显示了自我参照处理与社会处理的功能差异：前-后梯度的社会处理和自我参照处理内侧顶叶皮层和特定的激活自我，在内侧和外侧前额叶皮层的参考处理和颞顶叶交界处的社会处理。
Self-referential processing is a complex cognitive function, involving a set of implicit and explicit processes, complicating investigation of its distinct neural signature. The present study explores the functional overlap and dissociability of self-referential and social stimulus processing. We combined an established paradigm for explicit self-referential processing with an implicit social stimulus processing paradigm in one fMRI experiment to determine the neural effects of self-relatedness and social processing within one study. Overlapping activations were found in the orbitofrontal cortex and in the intermediate part of the precuneus. Stimuli judged as self-referential specifically activated the posterior cingulate cortex, the ventral medial prefrontal cortex, extending into anterior cingulate cortex and orbitofrontal cortex, the dorsal medial prefrontal cortex, the ventral and dorsal lateral prefrontal cortex, the left inferior temporal gyrus, and occipital cortex. Social processing specifically involved the posterior precuneus and bilateral temporo-parietal junction. Taken together, our data show, not only, first, common networks for both processes in the medial prefrontal and the medial parietal cortex, but also, second, functional differentiations for self-referential processing versus social processing: an anterior-posterior gradient for social processing and self-referential processing within the medial parietal cortex and specific activations for self-referential processing in the medial and lateral prefrontal cortex and for social processing in the temporo-parietal junction.