Circulating soluble selectins in Kawasaki disease
Circulating soluble selectins in Kawasaki disease
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DOI：
10.1046/j.1365-2249.1997.3852128.x
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发表时间：
1997-06-01
影响因子：
4.6
通讯作者：
Yoshioka, S
中科院分区：
文献类型：
--
作者：
Takeshita, S;Dobashi, H;Yoshioka, S
为了探讨川崎病（KD）中白细胞-内皮细胞相互作用相关的循环粘附分子的意义，采用ELISA法测定了16例川崎病（KD）患者、8例其他发热性疾病患者、6例过敏性紫癜（HSP）患者和10例健康儿童血清可溶性E-、P-、l -选择素（sE-、sP-、sl -选择素）和血管细胞粘附分子-1 （VCAM-1）的水平。急性期患者血清硒选择素水平显著高于其他各组（P < 0.01）。KD亚急性期sp -选择素水平显著高于其他各组（P < 0.01）。血清sl -选择素水平在KD恢复期有升高的趋势。KD患者se -选择素水平与c反应蛋白（r = 0.80, P < 0.001）、sp -选择素水平与血小板计数（r = 0.57, P < 0.0001）之间也存在显著相关性。这些数据表明，在KD的临床过程中，三种选择素的循环可溶性形式可能具有不同的动力学，这表明它们可能反映了其炎症过程。
To investigate the significance of circulating adhesion molecules associated with leucocyte-endothelial cell interaction in Kawasaki disease (KD), serum levels of soluble E-, P-, L-selectin (sE-, sP-, sL-selectin), and vascular cell adhesion molecule-1 (VCAM-1) were measured in 16 patients with KD, eight with other febrile diseases, six with Henoch-Schonlein purpura (HSP), and 10 healthy children using an ELISA. Serum sE-selectin levels from patients in the acute phase of KD were significantly higher than from those in other groups (P < 0.01). The levels of sP-selectin in the subacute phase of KD were significantly higher than in other groups (P < 0.01). Serum sL-selectin levels tended to rise in the convalescent phase of KD. There were also significant correlations between sE-selectin levels and C-reactive protein (r = 0.80, P < 0.001), and between sP-selectin levels and platelet counts (r = 0.57, P < 0.0001) in KD patients. These data indicate that circulating soluble forms of three selectins may have different kinetics during the clinical course of KD, suggesting that they may reflect its inflammatory process.