Multiple large hyperplastic polyps of the colon coincident with adenocarcinoma.
Multiple large hyperplastic polyps of the colon coincident with adenocarcinoma.
复制标题
结肠多发性大增生性息肉与腺癌一致。
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
Franz Fogt
中科院分区：
文献类型：
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作者：
Warner As;Michael E. Glick;Franz Fogt
小的增生性息肉是结肠最常见的非肿瘤性病变。通常，它们是小的（< 0.5 cm）无底病变，缺乏细胞异型性，主要发生在结肠直肠乙状结肠区域。多发大的增生性息肉（bbb1cm）是罕见的。尽管小型增生性息肉与腺瘤性息肉或癌之间的关系存在争议，但关于大型增生性息肉的重要性的数据更少。我们报告一个病例56岁的男子谁被看到，因为疲劳，贫血，和隐血阳性大便。在空气造影钡灌肠检查和结肠镜检查中，发现多个外观相似的息肉在整个结肠中对称分布。然而，组织学检查显示16个1-2厘米大小的增生性息肉，多个小型增生性息肉，1个腺瘤性息肉，1个腺瘤性息肉包含高分化腺癌。由于多发大的增殖性息肉是罕见的，我们怀疑这种实体可能不同于小的增殖性息肉。在我们的病人中，大的增生性息肉对称地分布于整个结肠，并伴有同步癌。由于大的增生性息肉可能与腺瘤性息肉和结肠癌同时发生，我们建议发现有大的增生性息肉的患者切除所有的息肉进行组织学检查。
Diminutive hyperplastic polyps are the most common non-neoplastic lesions of the colon. Typically, they are small (< 0.5 cm) sessile lesions, lack cellular atypia, and are found predominantly in the rectosigmoid region of the colon. Multiple large hyperplastic polyps (> 1 cm) are rare. Although the relationship between diminutive hyperplastic polyps and adenomatous polyps or carcinoma is controversial, even less data are available on the significance of large hyperplastic polyps. We report the case of a 56-yr-old man who was seen because of fatigue, anemia, and Hemoccult-positive stool. On air contrast barium enema study and colonoscopy, multiple polyps that were similar in appearance were found distributed symmetrically throughout the colon. However, histologic examination revealed 16 hyperplastic polyps 1-2 cm in size, multiple diminutive hyperplastic polyps, one adenomatous polyp, and one adenomatous polyp containing well-differentiated adenocarcinoma. Because multiple large hyperplastic polyps are rare, we suspect this entity may be distinct from diminutive hyperplastic polyps. In our patient, large hyperplastic polyps were distributed symmetrically throughout the colon and were associated with a synchronous carcinoma. Because large hyperplastic polyps may be coincident with adenomatous polyps and carcinoma of the colon, we recommend that patients found to have large hyperplastic polyps undergo removal of all polyps for histologic study.