Important Finding for COVID-19 Pandemic: Hydrocephalus-producing effect of Vaporized Alcohol Disinfectant
Important Finding for COVID-19 Pandemic: Hydrocephalus-producing effect of Vaporized Alcohol Disinfectant
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COVID-19 大流行的重要发现：汽化酒精消毒剂产生脑积水的作用
DOI：
10.1055/a-1962-1491
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
R. Demirtaş
中科院分区：
文献类型：
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作者：
A. Kanat;M. Aydın;Balkan Sahin;İskender Samet Daltaban;M. Gel;A. Guvercin;R. Demirtaş
摘要 背景 酒精暴露可能导致脑积水，但汽化鼻酒精暴露对脉络丛和室管膜细胞的影响以及酒精暴露与脑积水之间的关系尚不清楚。对此课题进行了调查。方法 本研究使用 24 只雄性（∼380 g）Wistar 大鼠。将动物分为三组，即对照组、假手术组和研究组。研究组进一步分为两组，即暴露于低剂量或高剂量酒精的组。对脉络丛、室内室管膜细胞和心室体积进行评估和统计比较。结果 对照组、假手术组、低度酒精暴露组和高酒精暴露组的退化上皮细胞密度分别为22±5个、56±11个、175±37个和356±85个/mm 3 。对照组的Evans指数<34%，假手术组>36%，低剂量酒精暴露组（低剂量酒精组）>40%，高剂量酒精暴露组（高剂量酒精组）>50%。结论 发现酒精暴露导致脉络丛和室管膜细胞变性，伴有纤毛病变和侧脑室扩大或脑积水。在 COVID-19 大流行时代，我们的发现具有重要的功能，因为酒精经常被用于卫生和预防 Sars-Cov-2 病毒的传播。
Abstract Background Alcohol exposure may cause hydrocephalus, but the effect of vaporized nasal alcohol exposure on the choroid plexus, and ependymal cells, and the relationship between alcohol exposure and developing hydrocephalus are not well known. This subject was investigated. Methods Twenty-four male (∼380 g) Wistar rats were used in this study. The animals were divided into three groups, as the control, sham and study groups. The study group was further divided into two groups as the group exposed to low or high dose of alcohol. The choroid plexuses and intraventricular ependymal cells and ventricle volumes were assessed and compared statistically. Results Degenerated epithelial cell density of 22 ± 5, 56 ± 11, 175 ± 37, and 356 ± 85/mm 3 was found in the control, sham, low alcohol exposure, and high alcohol exposure groups, respectively. The Evans index was <34% in the control group, >36% in the sham group, >40% in the group exposed to low alcohol dose (low-dose alcohol group), and >50% in the group exposed to high dose of alcohol (high-dose alcohol group). Conclusions It was found that alcohol exposure caused choroid plexus and ependymal cell degeneration with ciliopathy and enlarged lateral ventricles or hydrocephalus. In the COVID-19 pandemic era, our findings are functionally important, because alcohol has often been used for hygiene and prevention of transmission of the Sars-Cov-2-virus.