The effect of the skull on event-related P300
The effect of the skull on event-related P300
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DOI：
10.1016/s1388-2457(01)00587-9
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发表时间：
2001-09-01
影响因子：
4.7
通讯作者：
Hegerl, U
中科院分区：
文献类型：
--
作者：
Frodl, T;Meisenzahl, EM;Hegerl, U
目的：事件相关电位（EP）显示具有高时间分辨率的神经元过程，而功能磁共振成像（fMRI）具有高空间分布。这两种技术提供的信息可以相互补充。然而，这种组合充满了困难，因为头骨或头皮可能干扰头皮记录的EP。本研究的目的是探讨这种影响的头骨和头皮厚度上的事件相关P300 potential.Methods：30名健康对照者进行了检查，使用听觉诱发的P300引起的一个标准的oddball范式。颅骨和头皮厚度采用冠状位T2加权磁共振成像（MRI）测定。结果：P3 b振幅与颞顶颅骨厚度显著相关（r = -0.42，P = 0.021;回归斜率为-1.14 muV/mm颅骨厚度），而头皮对P300无影响。额部亚成分P3 a的振幅与额部颅骨厚度无关。结论：因此，当调整颅骨厚度时，P300作为一种研究工具的实用性可以得到增强。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
Objectives: Event-related potentials (EP) indicate neuronal processes with a high temporal resolution, while functional magnetic resonance imaging (fMRI) has a high spatial distribution. Information from both techniques may complement each other. However, this combination is fraught with difficulty because of a possible interference of the skull or the scalp with scalp-recorded EP. The aim of the present study was to investigate this influence of skull and scalp thicknesses on event-related P300 potentials.Methods: Thirty healthy controls were examined using an auditory evoked P300 elicited by a standard oddball paradigm. Skull and scalp thicknesses were determined using coronal T2-weighted magnetic resonance imaging (MRI).Results: P3b-amplitudes were significantly correlated with temporo-parietal skull thickness (r = -0.42; P = 0.021; regression slope of - 1.14 muV/mm skull thickness), whereas scalp had no influence on P300. The amplitude of the more frontal subcomponent P3a was not related to frontal skull thickness.Conclusions: Therefore, the utility of P300 as a research tool can be enhanced when adjustment for skull thickness is made. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.